Effects of imipramine on responding reduced by methadone

Pharmacology, Biochemistry, and Behavior
J ClearyT Thompson

Abstract

Interactions between methadone and acute and chronic imipramine were studied in pigeons key pecking under a multiple variable interval 15-sec variable interval 150-sec schedule of food presentation. Both drugs decreased response rates at the highest doses. The VI 15-sec schedule was slightly more sensitive to acute drug administration than was the variable interval 150-sec schedule. Acute combinations of the two drugs neither ameliorated nor exacerbated the effects of either drug alone. Chronic imipramine alone had no lasting effect on responding. Unlike acute combinations, chronic imipramine lessened the rate reducing effect of methadone.

References

Nov 1, 1984·Pharmacology, Biochemistry, and Behavior·T ThompsonJ Cleary
Jan 1, 1982·Annals of the New York Academy of Sciences·G E WoodyB D Evans
Sep 1, 1959·British Journal of Pharmacology and Chemotherapy·P B BRADLEY, B J KEY
Feb 1, 1965·International Journal of Neuropharmacology·C KORNETSKY

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Citations

Jul 1, 1996·Psychopharmacology·J ClearyA S Levine
Oct 1, 1990·Pharmacology, Biochemistry, and Behavior·M J MacenskiT Thompson
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·J M RudskiA S Levine
May 1, 1994·Pharmacology, Biochemistry, and Behavior·C A KoveraJ Cleary
Jan 1, 1997·Pharmacology, Biochemistry, and Behavior·E O'HareJ R Mach
May 25, 2006·Drug and Alcohol Dependence·Véronique Lelong-BoulouardAntoine Coquerel
Sep 1, 1996·Journal of the Experimental Analysis of Behavior·D W SchaalM P Reilly

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