Effects of immunological sensitization on the responses and sensitivity of guinea pig airways to bronchoconstrictors. Modulation by selective inhibition of arachidonic acid metabolism

Canadian Journal of Physiology and Pharmacology
M H Saad, J F Burka


The force generated by tracheal spirals and lung parenchymal strips from normal and ovalbumin-sensitized guinea pigs was measured in vitro, after challenge with histamine, carbachol, leukotriene (LT) C4, LTD4, or a prostaglandin endoperoxide analog (U-44069). The responses and sensitivity of airway tissues to the above agonists were identical in normal and sensitized animals. Treatment of tracheal spirals with indomethacin (8.5 microM), phenidone (185 microM), and nordihydroguaiaretic acid (NDGA: 30 microM) reduced resting tension (tone) equally in both normal and sensitized trachea, but did not affect lung parenchymal strips from either group. The responses of tracheal spirals from normal and sensitized animals to low concentrations of histamine, carbachol, LTC4, and LTD4 were reduced or abolished by treatment with the above inhibitors. Responses to higher concentrations of the same agonists were significantly enhanced. In contrast, treatment of normal and sensitized trachea with indomethacin (2.8 and 8.5 microM) did not abolish or reduce the effects of low concentrations of U-44069. However, an enhancement of the effect of high concentrations occurred only on normal tracheal spirals, even though the control tissues from each ...Continue Reading


Mar 29, 1989·European Journal of Pharmacology·J CortijoE J Morcillo
May 1, 1983·Prostaglandins·M H SaadJ F Burka
Jan 1, 1987·International Journal of Immunopharmacology·L J RobichaudR L Adolphson
Jul 1, 1990·Journal of Ethnopharmacology·M E Addy, J F Burka
May 1, 1997·Respiration Physiology·N BarakS Cohen
Aug 1, 1992·British Journal of Pharmacology·J R Thorne, K J Broadley
Apr 23, 2011·Pulmonary Pharmacology & Therapeutics·Pasquale Chitano
Aug 1, 1995·Journal of Autonomic Pharmacology·J C BidonA Jondet

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U 44069
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