Effects of immunosuppressants on immune response to vaccine in inflammatory bowel disease

Chinese Medical Journal
Yuan CaoZhi-Hua Ran

Abstract

To evaluate the response rate to vaccination in different treatment groups (nonimmunosuppressants and immunosuppressants). We completed an online systematic search using PubMed to identify all articles published in English between January 1990 and December 2013 assessing the effect of the response rate to vaccination in different treatment groups (with and without immunomodulators). The following terms were used: "inflammatory bowel disease (IBD)" OR "Crohn's disease" OR "ulcerative colitis" AND ("vaccination" OR "vaccine") AND ("corticosteroids" OR "mercaptopurine" OR "azathioprine" OR "methotrexate [MTX]") AND "immunomodulators." The inclusion criteria of articles were that the studies: (1) Randomized controlled trials which included patients with a diagnosis of IBD (established by standard clinical, radiographic, endoscopic, and histologic criteria); (2) exposed patients received immunomodulators for maintenance (weight-appropriate doses of 6-mercaptopurine/azathioprine or within 3 months of stopping, 15 mg or more MTX per week or within 3 months of stopping; (3) exposed patients received nonimmunomodulators (no therapy, antibiotics only, mesalazine only, biological agent only such as infliximab, adalimumab, certolizumab or ...Continue Reading

References

Oct 9, 2004·Inflammatory Bowel Diseases·Bruce E SandsWalter Orenstein
Dec 22, 2004·Journal of Gastroenterology and Hepatology·T Jacob JohnUNKNOWN Steering Committee for the Prevention and Control of Infectious Diseases in Asia
Oct 29, 2005·Arthritis and Rheumatism·Joachim ListingAngela Zink
Jun 5, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Petar MamulaRobert N Baldassano
Jun 16, 2007·Cleveland Clinic Journal of Medicine·Paul V Targonski, Gregory A Poland
Nov 1, 2007·The American Journal of Gastroenterology·Marcus A WörnsThomas Höhler
Dec 7, 2007·Gastroenterology·Susan M HutflessLisa J Herrinton
Dec 23, 2008·The American Journal of Gastroenterology·Carme LorasUNKNOWN GETECCu (Grupo Español de Enfermedades de Crohn y Colitis Ulcerosa)
Jan 29, 2009·The American Journal of Gastroenterology·Ying LuAthos Bousvaros
Mar 10, 2009·Medicina clínica·Luis Vida PérezJuan Francisco De Dios Vega
Sep 17, 2009·The American Journal of Gastroenterology·Gil Y MelmedEric A Vasiliauskas
Nov 4, 2009·Inflammatory Bowel Diseases·Jean-Baptiste ChevauxLaurent Peyrin-Biroulet
Jan 28, 2010·The American Journal of Gastroenterology·Sharmeel K WasanFrancis A Farraye
Mar 10, 2010·Current Drug Targets·Emma L Culver, Simon P L Travis
May 19, 2010·Inflammatory Bowel Diseases·Jason K HouUma Mahadevan
Sep 10, 2010·The New England Journal of Medicine·Klaus R Herrlinger, Eduard F Stange
Sep 21, 2010·The New England Journal of Medicine·Cesare RuffoloNicolò Bassi
Dec 3, 2010·Journal of Crohn's & Colitis·A DignassUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Jun 1, 2009·Journal of Crohn's & Colitis·J F RahierUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Dec 8, 2011·Digestive Diseases and Sciences·Mustafa Erhan AltunözAyşe Oya Kurdaş Ovünç
Jan 25, 2013·Annals of the Rheumatic Diseases·Shunsuke MoriKazunori Oishi
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Sarah MoberleyRoss M Andrews
Oct 23, 2013·Journal of Crohn's & Colitis·Chang Kyun LeeUNKNOWN Korean Association for the Study of Intestinal Diseases (KASID) Study
Aug 28, 2014·Expert Review of Gastroenterology & Hepatology·Athanasios P DesalermosSharmeel K Wasan

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Citations

Jun 18, 2019·The American Journal of Gastroenterology·Laure F PittetUNKNOWN Swiss Inflammatory Bowel Disease Cohort Study Group
Jul 19, 2016·Photochemistry and Photobiology·Keiichi HiramotoEisuke F Sato
Feb 1, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·Z A GoncharovaV A Megeryan
May 20, 2017·Chinese Medical Journal·Yan-Ling GeMei Zeng
Jan 23, 2021·Journal of the American Academy of Dermatology·Louise M GreshamMark G Kirchhof
May 1, 2021·Pharmacology Research & Perspectives·Hajar Alsaleh, Thamir M Alshammari
Jun 13, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Fabio Salvatore MacalusoMassimo Galli

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