PMID: 2116947Jun 1, 1990Paper

Effects of improved blood glucose on insulin-induced hypoglycaemia, TRH, GnRH and exercise tests in insulin-dependent diabetes

Clinical Endocrinology
M I WurzburgerR W Morris

Abstract

In order to evaluate effects of metabolic control on pituitary function in insulin-dependent diabetes exercise, hypoglycaemia (insulin tolerance test), thyrotrophin releasing hormone and gonadotrophin releasing hormone, tests were performed on 25 patients before (Study 1) and after 2 weeks of improved metabolic control (Study 2). Patients were sub-divided into C-peptide negative (CpN, 10 patients with no residual C-peptide secretion) and C-peptide positive (CpP, 15 patients with residual beta-cell function) groups for analysis of results. Exercise induced higher growth hormone responses in CpN patients independent of metabolic control (P less than 0.001). Thyrotrophin releasing hormone induced higher growth hormone responses in CpN patients; this response was threefold greater after improved control (P less than 0.005). Growth hormone and cortisol response to hypoglycaemia and thyroid stimulating hormone and prolactin secretion in response to thyrotrophin releasing hormone were unaffected by residual beta-cell function or metabolic control. Luteinizing hormone response to gonadotrophin releasing hormone in CpN patients was impaired and lower after improved control (P less than 0.002). The results indicate an association between...Continue Reading

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Citations

Mar 19, 1991·Biochimica Et Biophysica Acta·E MeldrumA Carozzi
Oct 1, 1991·Molecular and Cellular Endocrinology·J A FloresD A Leong
Feb 1, 1996·Medical Hypotheses·M I Wurzburger, P H Sönksen
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Jan 6, 2006·Endocrine Research·LuGuang Luo, Naohiro Yano

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