Effects of improved complementary feeding and improved water, sanitation and hygiene on early child development among HIV-exposed children: substudy of a cluster randomised trial in rural Zimbabwe.

BMJ Global Health
Jaya ChandnaMelissa Gladstone

Abstract

HIV-exposed uninfected children may be at risk of poor neurodevelopment. We aimed to test the impact of improved infant and young child feeding (IYCF) and improved water, sanitation and hygiene (WASH) on early child development (ECD) outcomes. Sanitation Hygiene Infant Nutrition Efficacy was a cluster randomised 2×2 factorial trial in rural Zimbabwe ClinicalTrials.gov NCT01824940). Pregnant women were eligible if they lived in study clusters allocated to standard-of-care (SOC; 52 clusters); IYCF (20 g small-quantity lipid-based nutrient supplement/day from 6 to 18 months, complementary feeding counselling; 53 clusters); WASH (pit latrine, 2 hand-washing stations, liquid soap, chlorine, play space, hygiene counselling; 53 clusters) or IYCF +WASH (53 clusters). Participants and fieldworkers were not blinded. ECD was assessed at 24 months using the Malawi Developmental Assessment Tool (MDAT; assessing motor, cognitive, language and social skills); MacArthur Bates Communication Development Inventory (assessing vocabulary and grammar); A-not-B test (assessing object permanence) and a self-control task. Intention-to-treat analyses were stratified by maternal HIV status. Compared with SOC, children randomised to combined IYCF +WASH ha...Continue Reading

Associated Clinical Trials

References

Jan 1, 1994·Journal of Child Psychology and Psychiatry, and Allied Disciplines·E M Cummings, P T Davies
Jan 5, 2002·Child Development·S M Petterson, A B Albers
Nov 20, 2012·Journal of the International Neuropsychological Society : JINS·Margaret NampijjaKatie J Alcock
Oct 14, 2014·Paediatrics and International Child Health·Andrew J Prendergast, Jean H Humphrey
Nov 26, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·UNKNOWN Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial TeamJames M Tielsch
Apr 7, 2016·The Lancet Infectious Diseases·Ceri EvansAndrew J Prendergast
Jan 28, 2018·Pediatrics·Megan S McHenryRachel C Vreeman
Apr 4, 2018·Pediatrics·Jessica E RastAlice Kuo
May 13, 2018·Journal of Health, Population, and Nutrition·Elizabeth L PradoKathryn G Dewey
Dec 18, 2018·The Lancet Global Health·Jean H HumphreyUNKNOWN Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial Team

❮ Previous
Next ❯

Citations

Jan 25, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ceri EvansUNKNOWN Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial Team
Nov 19, 2020·PloS One·Hlengiwe P MadlalaMarie-Louise Newell
Apr 6, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Reshma SirajeeMichael T Hawkes

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

SHINE
Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved