Effects of in-utero exposure to chemotherapy on fetal brain growth

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Sofia PasseraMonica Fumagalli

Abstract

Children exposed to chemotherapy in the prenatal period demonstrate normal neurocognitive development at 3 years but concerns regarding fetal brain growth remain high considering its vulnerability to external stimuli. Our aim was to evaluate the impact of in-utero chemotherapy exposure on brain growth and its effects on neurodevelopmental outcome. The protocol was approved by the local ethics committee. Brain regional volumes at term postmenstrual age were measured by MRI in children exposed to in-utero chemotherapy and compared with normal MRI controls. Brain segmentation was performed by Advanced Normalization Tools (ANTs)-based transformations of the Neonatal Brain Atlas (ALBERT). Neurodevelopmental assessment (Bayley-III scales) was performed at 18 months corrected age in both exposed infants and in a group of healthy controls. Multiple linear regressions and false discovery rate correction for multiple comparisons were performed. Twenty-one newborns prenatally exposed to chemotherapy (epirubicin administered in 81% of mothers) were enrolled in the study: the mean gestational age was 36.4±2.4 weeks and the mean birthweight was 2,753±622 g. Brain MRI was performed at mean postmenstrual age of 41.1±1.4 weeks. No statistically...Continue Reading

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Citations

Feb 7, 2020·Current Oncology Reports·Charlotte MaggenUNKNOWN International Network on Cancer, Infertility and Pregnancy (INCIP)
Mar 3, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Vera WoltersFrédéric Amant

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