Effects of in utero exposure to Tityus bahiensis scorpion venom in adult rats

Neurotoxicology and Teratology
Ana Leticia C DorceAna Leonor A Nencioni

Abstract

The toxicity of Tityus bahiensis scorpion venom is well known, but there are little data about the damage in offspring of dams that were exposed to the venom during pregnancy. The objective of this work was to determine the toxic effects of venom in adult offspring of Wistar rats exposed to venom in utero. Dams were divided into a control group, subcutaneously injected with saline solution on the 10th (GD10) and 16th (GD16) days, and two experimental groups, subcutaneously injected with venom (2.5mg/kg) on GD10 or GD16, respectively. Adult offspring were evaluated according to behavioral development and neuronal integrity in the hippocampus. Tests performed in the activity box and in the enriched environment demonstrated that males from GD10 had motor decrease. Females from GD10 showed a depressive-like state and were more anxious, as demonstrated by the forced swimming test and social interaction. The plus-maze discriminative avoidance task demonstrated that GD16 males had lower levels of anxiety. The number of neuronal cells was decreased in CA1, CA3 and CA4 hippocampal areas of males and females from GD10 group and in CA1 of females and CA4 of males from GD16 group. Thus, we conclude that venom exposure in pregnant dams caus...Continue Reading

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Citations

Feb 14, 2014·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Ana Leticia C DorceAna Leonor A Nencioni
Jan 10, 2016·Reproductive Toxicology·Adriana do Nascimento MartinsValquíria Abrão Coronado Dorce
Jul 5, 2015·Toxicon : Official Journal of the International Society on Toxinology·Ana L C DorceAna L A Nencioni
Jun 21, 2017·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Ana Leticia Coronado DorceAna Leonor Abrahão Nencioni

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