Effects of in vitro HIV-1 infection on mycobacterial growth in peripheral blood monocyte-derived macrophages.

Infection and Immunity
Sharad PathakBirgitta Asjo

Abstract

Coinfection with human immunodeficiency virus type 1 (HIV-1) and opportunistic mycobacteria, especially Mycobacterium tuberculosis, is a cause of high morbidity and mortality worldwide. Both mycobacteria and HIV-1 may infect macrophages, and thus, coinfection may generate conditions that reciprocally influence the intracellular replication of the pathogens. Elucidation of the interaction between HIV-1 and mycobacteria in their common target cell is important for understanding pathogenesis in coinfected individuals. In this study, we investigated the effects of in vitro HIV-1 infection on the growth of M. tuberculosis, M. avium, and M. paratuberculosis in human peripheral blood monocyte-derived macrophages. Interestingly, HIV-1 infection induced a greater bacterial burden in coinfected cell cultures for all of the mycobacterial species tested and specifically induced accelerated growth of M. tuberculosis with a reduced mean generation time. The interaction of HIV-1 and M. tuberculosis was especially detrimental to the host cell, causing a significant synergistic reduction in macrophage viability. Also, in M. tuberculosis/HIV-1-coinfected cultures, increased levels of interleukin-1beta (IL-1beta), IL-6, IL-8, and granulocyte-macr...Continue Reading

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Citations

Jan 7, 2014·Tuberculosis·Sudhamathi VijayakumarJanice J Endsley
Apr 25, 2013·Nature Communications·Monty LiongRalph Weissleder
May 9, 2013·Future Virology·Naomi F WalkerRobert J Wilkinson
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Mar 1, 2018·Annual Review of Immunology·Hanif EsmailRobert J Wilkinson
Feb 13, 2018·The Journal of Infectious Diseases·Nargis Khan, Maziar Divangahi
Nov 8, 2017·Nature Reviews. Microbiology·Lucy C K Bell, Mahdad Noursadeghi
Apr 5, 2018·Scientific Reports·Milena S EspíndolaFabiani G Frantz
Jan 27, 2021·Annual Review of Pathology·Rachel L KinsellaChristina L Stallings
Jan 14, 2017·Microbiology Spectrum·Elsa Du Bruyn, Robert John Wilkinson
Feb 6, 2017·Microbiology Spectrum·Thomas J ScribaHelen A Fletcher

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