PMID: 9419018Jan 7, 1998Paper

Effects of in-vivo generation of oxygen free radicals on immune responsiveness in rabbits

Immunology Letters
B C KonerA Ray

Abstract

Oxygen free radicals (OFRs) generated during biological processes are reportedly involved in the pathogenesis of several disease states and various reports have indicated that oxidative stress may alter immune competence. Hence, effects of in-vivo generation of OFRs by using xanthine/xanthine oxidase (X/XO) system on immune responsiveness were evaluated in rabbits. Intravenous injections of xanthine (0.14 mg/kg) along with xanthine oxidase (2 U/Kg) following primary and secondary immunizations of animals with sheep red blood cells (SRBC) significantly attenuated the primary and secondary antibody responses respectively. In tests for cell-mediated immunity, tuberculin sensitivity and leucocyte migration inhibition were also decreased significantly in sensitized animals following X/XO treatment. The observed changes in both humoral and cell-mediated immune responses following such in-vivo generation of OFRs indicate a possible nexus between OFR generation and immune suppression.

Citations

Feb 9, 2006·Neurotoxicity Research·Jucéla J FortunatoJoão Quevedo
Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·M AgostonA Vereckei
Jul 22, 1999·Toxicology Letters·B D BanerjeeA K Chakraborty
Jul 21, 2006·Journal of Toxicology and Environmental Health. Part a·Rentian FengVincent Castranova
Jul 14, 2010·Ecotoxicology and Environmental Safety·Marie L HannamMalcolm B Jones
Jul 28, 2009·Veterinary Immunology and Immunopathology·Asunción RamosMaría-Prado Míguez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.