Effects of in vivo-like activation frequency on the length-dependent force generation of skeletal muscle fibre bundles

European Journal of Applied Physiology and Occupational Physiology
C J ZuurbierP A Huijing

Abstract

It is known that a range of firing frequencies can be observed during in vivo muscle activity, yet information is lacking as to how different in vivo-like frequencies may affect force generation of skeletal muscle. This study examined the effects of constant (CSF, constant within one contraction) and decreasing stimulation frequencies (DSF) on mean sarcomere length-force characteristics of rat gastrocnemius medialis fibre bundles. The CSF resulted in an optimal mean sarcomere length (lso) of 2.30 (SEM 0.02), 2.46 (SEM 0.03), 2.76 (SEM 0.03) and more than 2.99 (SEM 0.07) lm, for 100, 50, 30 and 15 Hz, respectively. Compared to 100-Hz stimulation, both lso and the ascending limb of the relationship significantly shifted to higher lengths with lower frequencies. No shift was encountered for the initial part of the descending limb. The DSF reduced the frequency-induced shift to higher mean lengths [lso 2.33 (SEM 0.02), 2.52 (SEM 0.08) and more than 2.92 (SEM 0.10) microm, respectively, for 50, 30 and 15 Hz]. No effect of activation time on length-force characteristics was observed. It was concluded from these studies that the frequency and history of stimulation is a major determinant of the length-force characteristics of muscle f...Continue Reading

Citations

Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mark J C SmeuldersPeter A Huijing
Jul 29, 1998·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·P A Huijing
Jan 29, 2010·Proceedings. Biological Sciences·Emanuel Azizi, Thomas J Roberts
Dec 16, 2006·Biological cybernetics·Dinant A KistemakerMaarten F Bobbert
Jul 19, 2005·Journal of Biomechanics·Dinant A KistemakerMaarten F Bobbert
Oct 6, 2005·Journal of Muscle Research and Cell Motility·Franklin Fuchs, Donald A Martyn
Sep 2, 2000·Motor Control·M B Shapiro, R V Kenyon

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