PMID: 6977503Jan 1, 1981Paper

Effects of in vivo treatments with cyclosporin-A on mouse cell-mediated immune responses

International Journal of Immunopharmacology
S AlbertiA Tagliabue

Abstract

The fungal metabolite Cyclosporin-A (CyA) was investigated for its activity on several cell-mediated immune responses. Oral administration of 70 mg kg-1 of CyA for 5 days to C3H/HeN mice completely abolished the in vivo antigen-dependent production of a lymphokine capable of increasing macrophage cytotoxicity against tumor cells. Moreover, spleen cells from CyA treated mice were significantly depressed in their ability to produce in vitro lymphokines in response to PHA, whereas only a slight depression was observed when ConA was employed to induce lymphokine production. In parallel to the depression of proliferation-independent immune response, spleen cells from CyA treated mice showed a strongly depressed proliferative response to PHA, marginal reduction being observed in the response to ConA. B-lymphocytes did not seem to be affected by in vivo treatment with CyA, judging from the proliferative responses to LPS. Macrophage responses also remained unaltered after CyA treatment. No depressions in natural or lymphokine-induced macrophage cytotoxicity and in monokine production were in fact observed in CyA treated mice. Finally, a short-lived depression of natural killer (NK) activity was observed after CyA administration. These ...Continue Reading

References

Jul 1, 1976·Agents and Actions·J F BorelH Stähelin
Jul 1, 1979·Cellular Immunology·A TagliabueJ L McCoy
Jul 15, 1969·International Journal of Cancer. Journal International Du Cancer·S KitD R Dubbs
Jan 1, 1980·Immunobiology·D Wiesinger, J F Borel
Feb 1, 1981·Transplantation·M IntronaA Mantovani

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Citations

Oct 1, 1984·Agents and Actions·A W ThomsonJ G Simpson
Jan 1, 1984·International Journal of Immunopharmacology·V M RumjanekJ Morley
May 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·P RudgeT Poole
Jul 1, 1987·Infection and Immunity·T Takashima, F M Collins

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