PMID: 11931526Apr 5, 2002Paper

Effects of inactivity on glycolytic capacity of single skeletal muscle fibers in adult and aged rats

Biological Research for Nursing
B E OjalaL V Thompson

Abstract

The purpose of this study was to determine the effects of inactivity on lactate dehydrogenase (LDH) enzyme activity (expressed in nmol/g dry weight x hour) in single skeletal musclefibers from the soleus muscle in adult and aged rats. Fourteen 12-month-old andfifteen 30-month-old Fisher 344 Brown Norway F1 Hybrid rats were randomly assigned to control, 1 week of hindlimb unweighting (HU1), or 2 weeks of hindlimb unweighting (HU2). With age, a significant decrease in LDH enzyme activity occurred in type I skeletal muscle fibers (29.5%, P < 0.05). Following HU2, individual type I skeletal muscle fibers from the 12-month-old animals showed a 33.3% increase in LDH activity. In contrast, individual type I fibers from the aged animals showed a 50.0% increase after HU1. In conclusion, the baseline levels of LDH activity were significantly less in aged versus adult rats. The timing of the skeletal muscle adaptation to inactivity was different between young and old animals, such that the older animals responded to inactivity before the younger animals. These biochemical changes may have an impact on the fatigability of the muscle following inactivity. Thefindings indicate that treatment during bed rest for the older adult may be differe...Continue Reading

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Citations

Dec 17, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Russell T HeppleDavid J Baker
Apr 29, 2009·Journal of Ethnopharmacology·Cheng-Jie ChenMin Li
Nov 21, 2007·Seminars in Oncology Nursing·Carolyn Ingram, Constance Visovsky
Feb 7, 2006·Seminars in Oncology Nursing·Constance Visovsky
Jul 26, 2015·Journal of Translational Medicine·Annamaria De LucaDiana Conte Camerino
Jul 1, 2005·The Journal of Nutrition·T P Stein, C E Wade

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