Effects of incision and irradiation on regional lymph node metastasis in carcinoma of the hamster tongue

Oral Surgery, Oral Medicine, and Oral Pathology
K OhtakeT Nakajima

Abstract

The effects of incision and irradiation on regional lymph node metastasis in DMBA-induced squamous cell carcinomas of the hamster tongue are reported. Metastasis to the submandibular lymph nodes was confirmed histologically in 48.0% of the animals. The incidence of lymph node metastasis was significantly increased (65.9%) after repeated incisions of tongue carcinomas. Three gray whole-body irradiation also increased the rate of metastasis from 31.0% to 46.3%. Higher incidences of lymphatic vessel invasion after incision and concomitant lymph node metastasis in the lymphatic invasion-positive group indicated a stepwise relationship leading to an increase in lymph node metastasis after incision. Because of the high incidence of metastases and close resemblance to human carcinomas in the tumor cell deposition and establishment of metastatic foci, DMBA-induced tongue carcinoma with invasion may serve as an experimental model of human oral carcinomas.

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Citations

Aug 21, 2012·The British Journal of Oral & Maxillofacial Surgery·Hidenori TakahashiTakahide Komori
Jul 16, 2010·International Journal of Oral and Maxillofacial Surgery·J SeoaneP Varela-Centelles
Dec 24, 2010·Australian Dental Journal·A M FrydrychL M Slack-Smith
Jul 14, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Dong ChenXiaohui Jiao
Apr 18, 2015·BMC Oral Health·Matthias Christian WurmCornelius von Wilmowsky
Feb 1, 1995·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·O HjortdalA Berner
Apr 1, 1993·Oral Surgery, Oral Medicine, and Oral Pathology·K OhtakeT Nakajima

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