PMID: 8949689Sep 1, 1996Paper

Effects of increased red cell mass on subclinical tissue acidosis in hyaline membrane disease

Archives of Disease in Childhood. Fetal and Neonatal Edition
E F La GammaP A Auld

Abstract

To determine whether there are subclinical deficits in oxygen delivery in ventilated premature neonates. Ventilated premature neonates weighing less than 1500 g, who were transfused for anaemia or who were given colloids for clotting abnormalities (or oedema), were haemodynamically monitored during the first week of life. Calf muscle surface pH (pH) was measured in conjunction with peripheral limb blood flow by occlusion plethysmography. Packed red blood cell transfusions corrected a subclinical regional tissue acidosis (low tpH) without affecting arterial pH or limb blood flow. This observation also correlated with an increase in regional oxygen delivery. The data were also suggestive of a pattern of pathological, supply dependent, oxygen delivery and are similar to other observations made in adults with adult respiratory distress syndrome. Packed red blood cells increase regional oxygen delivery and tissue surface pH. In contrast, colloid infusion provided no substantial cardiovascular or metabolic benefit to these patients and should be avoided when oxygen delivery is at issue and when there may be leaky pulmonary capillaries.

References

Dec 1, 1979·Developmental Medicine and Child Neurology·S WaldmanP A Auld
Oct 1, 1992·Archives of Disease in Childhood·E F EmeryH R Gamsu
Mar 18, 1992·JAMA : the Journal of the American Medical Association·R S Hotchkiss, I E Karl
Jul 1, 1992·The American Review of Respiratory Disease·J P MortolaD Mayer
Mar 1, 1992·Annals of Internal Medicine·H G WelchL T Goodnough
Aug 1, 1991·American Journal of Diseases of Children·R G Strauss
Aug 1, 1991·Critical Care Medicine·G R DoglioG Gutierrez
Jul 24, 1991·JAMA : the Journal of the American Medical Association·E C Rackow, M E Astiz
Jul 1, 1991·The Journal of Pediatrics·J A EnglundH H Balfour
Dec 1, 1990·Critical Care Medicine·P Sasidharan, R Heimler
Jul 1, 1990·Transfusion·R G StraussC Sotelo-Avila
Jul 1, 1990·Archives of Disease in Childhood·I HudsonC A Wardrop
Dec 1, 1989·Early Human Development·S BignallJ Wadsworth
Mar 1, 1988·Archives of Disease in Childhood·A GreenoughH R Gamsu
Feb 1, 1986·Pediatric Clinics of North America·J A Stockman
Jul 24, 1987·JAMA : the Journal of the American Medical Association·B A Mizock
Jun 1, 1972·Archives of Surgery·J M Van de WaterW R Fisher
Feb 1, 1971·Annals of Surgery·N P CouchF D Moore
Aug 1, 1980·Anaesthesia and Intensive Care·P L GaudryD Joseph
Aug 1, 1994·The Journal of Pediatrics·C LachanceH Bard
Jan 19, 1994·JAMA : the Journal of the American Medical Association·A L Beal, F B Cerra
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·J A Russell, P T Phang
Aug 1, 1993·The Journal of Pediatrics·M SeearA MacNab
Sep 8, 1993·JAMA : the Journal of the American Medical Association·N MaynardI McColl
Oct 13, 1993·JAMA : the Journal of the American Medical Association·J J RoncoK R Walley
Feb 1, 1993·Critical Care Medicine·D R Dantzker
Feb 1, 1993·Critical Care Medicine·C M Grum
Jun 16, 1993·JAMA : the Journal of the American Medical Association·P E Marik, W J Sibbald

❮ Previous
Next ❯

Citations

May 25, 2012·Asian Journal of Transfusion Science·Shereen AbdelghaffarDina Mohamed
May 1, 2015·Journal of Perinatology : Official Journal of the California Perinatal Association·J P MintzerE F LaGamma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.