PMID: 107511Jan 31, 1979

Effects of increasing arterial pressure on cerebral blood flow in the baboon: influence of the sympathetic nervous system

Pflügers Archiv : European journal of physiology
E T MacKenzieA M Harper

Abstract

The influence of stimulation of the cervical sympathetic chain on the response of cerebral blood flow to hypertension induced by the intravenous infusion of angiotensin was studied in anaesthetised baboons. Cerebral blood flow was measured by the intracarotid 133Xenon injection technique. Possible lesions of the blood-brain barrier were studied by injecting Evans blue towards the end of the experiment and ischaemic brain damage was assessed following perfusion fixation. In a control group of five baboons blood flow increased by 53 +/- 9% (mean +/- S.E.) from the base line values in the arterial pressure range 130-159 mm Hg. In four baboons subjected to unilateral sympathetic stimulation flow increased by 16 +/- 4% in the same pressure range. In three baboons subjected to bilateral sympathetic stimulation there were no significant increases in flow until the arterial pressure had increased above 159 mm Hg. Disruption of the blood-brain barrier in the parietooccipital regions was only seen in the control animals but not in the stimulated baboons. Ischaemic brain damage was not observed with the exception of one small lesion in a single stimulated baboon. These findings provide strong support for the observations of Bill and Linde...Continue Reading

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Related Concepts

Angiotensin II, Val(5)-
Anthropoidea
Diastolic Blood Pressure
Blood - Brain Barrier Anatomy
Brain
Cerebrovascular Circulation
Hypertensive Disease
Papio
Sympathetic Nervous System

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