Effects of increasing docosahexaenoic acid intake in human healthy volunteers on lymphocyte activation and monocyte apoptosis.

The British Journal of Nutrition
Saïda MebarekAnnie-France Prigent

Abstract

Dietary intake of long-chain n-3 PUFA has been reported to decrease several markers of lymphocyte activation and modulate monocyte susceptibility to apoptosis. However, most human studies examined the combined effect of DHA and EPA using relatively high daily amounts of n-3 PUFA. The present study investigated the effects of increasing doses of DHA added to the regular diet of human healthy volunteers on lymphocyte response to tetradecanoylphorbol acetate plus ionomycin activation, and on monocyte apoptosis induced by oxidized LDL. Eight subjects were supplemented with increasing daily doses of DHA (200, 400, 800, 1600 mg) in a TAG form containing DHA as the only PUFA, for 2 weeks each dose. DHA intake dose-dependently increased the proportion of DHA in mononuclear cell phospholipids, the augmentation being significant after 400 mg DHA/d. The tetradecanoylphorbol acetate plus ionomycin-stimulated IL-2 mRNA level started to increase after ingestion of 400 mg DHA/d, with a maximum after 800 mg intake, and was positively correlated (P < 0.003) with DHA enrichment in cell phospholipids. The treatment of monocytes by oxidized LDL before DHA supplementation drastically reduced mitochondrial membrane potential as compared with native ...Continue Reading

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Citations

May 22, 2010·The British Journal of Nutrition·Jennifer LefilsNathalie Bernoud-Hubac
Feb 18, 2011·Journal of Atherosclerosis and Thrombosis·Maxime NowakBernard Lacour
Aug 3, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Birgitta Strandvik
May 8, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Michel LagardeEvelyne Véricel
Apr 24, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M LagardeE Véricel
May 31, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Michaela C PascoeDavid P Crewther
Sep 30, 2014·Biochimica Et Biophysica Acta·Michel GuichardantEvelyne Véricel
Aug 16, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Michel LagardeEvelyne Véricel

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