Effects of increasing doses of apomorphine during stereotaxic neurosurgery in Parkinson's disease: clinical score and internal globus pallidus activity. Short communication

Journal of Neural Transmission
A StefaniG Bernardi

Abstract

We analysed the firing activity of internal globus pallidus cells in two Parkinson's disease patients undergoing stereotaxic surgery. Both patients showed an advanced rigid-akinetic syndrome with disabling levodopa induced dyskinesias. Apomorphine, intraoperatively administered at doses (1-2 mg) inducing a short but clear clinical improvement without involuntary movements, reduced the pallidal discharge rate by > 50% in both patients. An higher apomorphine dose (2.5 mg), tested in one hemisphere, blocked the firing activity with a time course independent from the occurrence of dyskinesias. These finding suggest that the reduction of internal pallidus excitability is one of the mechanisms underlying the efficacy of dopaminergic therapy, but also that changes in other basal ganglia stations are likely to be involved in dyskinesias.

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Citations

Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Meg MorrisFrances Huxham
Dec 6, 2005·Experimental Brain Research·Alessandro StefaniPaolo Mazzone
Jan 22, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A StefaniP Stanzione
Sep 23, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J L MolinuevoJ Valls-Solé
Dec 3, 1999·The European Journal of Neuroscience·A StefaniG Bernardi
Sep 22, 2009·Journal of the Neurological Sciences·Stefani AlessandroAntonella Peppe
Sep 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·C Warren OlanowFabrizio Stocchi
Apr 12, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Leo Verhagen Metman, Shaun T O'Leary
Feb 5, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Salvatore Galati, Alessandro Stefani
Jan 13, 2018·Clinical Drug Investigation·Manon AuffretMarc Vérin
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A PeppeP Stanzione
Aug 3, 2001·Nature Reviews. Neuroscience·E BezardC E Gross
Jun 5, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·J D Speelman, D A Bosch
Jul 2, 2002·Journal of Neurophysiology·David N RuskinJudith R Walters

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