Effects of indapamide on endothelium-dependent relaxations in isolated canine femoral arteries

The American Journal of Cardiology
V B SchiniP M Vanhoutte

Abstract

Indapamide is an effective antihypertensive agent in humans and in experimental hypertensive animals. The aim of the present study was to investigate whether indapamide affects endothelium-dependent and independent relaxations in canine femoral arteries. Rings (with or without endothelium) were contracted with prostaglandin F2 alpha (2 X 10(-6) mol/liter) before the addition, in a cumulative fashion, of relaxing agents. Indapamide (10(-7) to 10(-4) mol/liter) had no direct effect on unstimulated or prostaglandin-stimulated preparations; it did not alter relaxations of preparations with endothelium induced by acetylcholine, bradykinin, adenosine diphosphate or the calcium ionophore A23187. Similarly, it did not affect relaxations induced by sodium nitroprusside, prostacyclin or forskolin in preparations with or without endothelium. Indomethacin shifted the concentration-response curve to bradykinin to the right and did not alter that to the other relaxing drugs. The reduced relaxation to bradykinin was reversed in a concentration-dependent manner by indapamide (10(-7) to 10(-5) mol/liter). In the presence of indomethacin, indapamide shifted the concentration response curve to prostacyclin (in rings with endothelium) and to forsk...Continue Reading

References

Jul 15, 1979·European Journal of Pharmacology·J Mironneau, Y M Gargouil
Apr 1, 1978·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·H UsuiN Toda
Jan 29, 1988·The American Journal of Medicine·J Mironneau
Jan 1, 1989·British Journal of Clinical Pharmacology·P M VanhoutteM J Vidal
Jan 1, 1986·Annual Review of Physiology·P M VanhoutteD S Houston
Jan 1, 1983·Current Medical Research and Opinion·M LeBelS Langlois
Jul 20, 1982·Biochimica Et Biophysica Acta·A R WhortonR S Kent
Jul 1, 1981·The Journal of Physiology·J G De Mey, P M Vanhoutte

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Citations

Mar 1, 1996·General Pharmacology·M KähönenI Pörsti
Jan 1, 1993·Fundamental & Clinical Pharmacology·C M BoulangerP M Vanhoutte
May 2, 1990·The American Journal of Cardiology·D B Campbell, F Brackman

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