Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice

Journal of Ethnopharmacology
Yun-Li ZhaoXiao-Dong Luo

Abstract

Leaf of Alstonia scholaris (L.) R. Br. (Apocynaceae), a wide used ethic-medicine in many Asia and Africa counties, has also been recorded as the common traditional Chinese medicine for treatment of illnesses in respiratory system by Dai people. To provide experimental data of clinical adaption of total indole alkaloids (TA) from leaf of A. scholaris for treating post-infectious cough in phase II clinical trial. To model post-infectious cough, all animals except control group were instilled intra-tracheal with lipopolysaccharide (LPS) (80 μg/50 µL/mouse), followed by subsequent exposure to cigarette smoke (CS) for 30 min per day for a total of 30 days. Mice were orally given TA at dose of 10, 25, 50 mg/kg, and four main alkaloids (Sch: scholaricine, Epi: 19-epischolaricine, Val: vallesamine, Pic: picrinine) once daily. Cellular infiltration was assessed in the broncho-alveolar lavage fluid (BALF). Expression of interleukin-6 (IL-6) and C-reactive protein (CRP) in the serum was determined, the superoxide dismutase (SOD) activity as well as malondialdehyde (MDA) content in the serum and homogenate were examined. Finally, histopathological examination in the lungs was assessed by H. E. staining. After administration of TA and four ...Continue Reading

Citations

Apr 3, 2020·Natural Products and Bioprospecting·Yun-Li ZhaoXiao-Dong Luo
Jan 4, 2021·Natural Products and Bioprospecting·Yun-Li ZhaoXiao-Dong Luo
Jan 16, 2021·Journal of Ayurveda and Integrative Medicine·Manohar S GundetiK S Dhiman
Jun 19, 2021·Bioorganic Chemistry·Jayanta DowarahVed Prakash Singh
Jul 31, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Saikat MitraJesus Simal-Gandara
Jul 24, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hong-Xia ZhouZi-Feng Yang

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Methods Mentioned

BETA
ELISA
MDA
light microscopy

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