PMID: 6404181Apr 1, 1983Paper

Effects of indomethacin on cerebral blood flow during hypercapnia in cats

The American Journal of Physiology
D W Busija, D D Heistad

Abstract

To study the contribution of prostaglandins to cerebral vasodilatation during hypercapnia, we inhibited prostaglandin synthesis with indomethacin. We measured cerebral blood flow (CBF) in anesthetized cats with 15-micrometers microspheres during normocapnia (PCO2 approximately 33 Torr), moderate hypercapnia (PCO2 approximately 49 Torr), and severe hypercapnia (PCO2 approximately 65 Torr) before and after intravenous administration of vehicle or indomethacin (3 and 10 mg/kg). Hypercapnia produced graded increments in blood flow to all areas of the brain. Administration of indomethacin did not change control CBF or significantly attenuate increases in CBF during hypercapnia. We examined efficacy and specificity of inhibition of prostaglandin synthesis by indomethacin using the cranial window method. Arachidonic acid (100 and 200 micrograms/ml) and acetylcholine (10(-7) and 10(-6)M or 10(-6) and 10(-5) M), dissolved in artificial cerebrospinal fluid, dilated pial arteries in a dose-dependent fashion. Intravenous administration of indomethacin blocked vasodilatation produced by arachidonic acid but did not affect the response to acetylcholine. Thus indomethacin, at a dose that effectively blocks prostaglandin synthesis, did not alt...Continue Reading

Citations

Sep 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S P DidionF M Faraci
Aug 1, 1994·Stroke; a Journal of Cerebral Circulation·F M FaraciD D Heistad
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F M FaraciN L Weintraub
Mar 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Robert M BryanSean P Marrelli

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