PMID: 7210704Dec 1, 1980Paper

Effects of inducers and/or inhibitors on metabolism of lysergic acid diethylamide in rat liver microsomes

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
T InoueT Murata


1. When lysergic acid diethylamide (LSD) was incubated with liver microsomes obtained from untreated rats, SKF 525-A inhibited most potently the hydroxylation at the 13-position, moderately inhibited N-demethylation at the 6-position, and least affected the metabolism of the side-chain at the 8 position. Furthermore, an atmosphere of 80% CO and 20% O2 (v/v) caused max. inhibition in N-demethylation, moderate inhibition in 13-hydroxylation, and the minimum in metabolism of the side-chain at the 8-position. These data suggested that the metabolism of LSD is catalysed by three separate enzyme systems. 2. The formation of 13-hydroxy-lysergic acid diethylamide (13-hydroxy-LSD) in liver microsomes obtained from 3-methylcholanthrene-treated rats was not inhibited by CO, although the hydroxylation required NADPH and oxygen. 3. The results of experiments using various inhibitors suggest that the 13-hydroxylation in liver microsomes from 3-methylcholanthrene-treated rats is catalysed by an enzyme system involving an unusual type of cytochrome P-448.


Mar 1, 1976·Archives of Biochemistry and Biophysics·H ShigematsuH Yoshimura
Apr 1, 1977·Chemical & Pharmaceutical Bulletin·H ShigematsuH Yoshimura
Jan 2, 1975·Biochemical and Biophysical Research Communications·V UllrichP Wollenberg
Mar 15, 1974·Biochemical Pharmacology·T NiwaguchiY Nakahara
Mar 12, 1968·Biochemical and Biophysical Research Communications·M SuzukiN B Myant
May 1, 1972·Archives of Biochemistry and Biophysics·D M Ziegler, C H Mitchell
May 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T InoueT Murata
Aug 1, 1958·The Journal of Clinical Endocrinology and Metabolism·G W LIDDLEA P HARRIS


Jun 28, 1996·Forensic Science International : Synergy·S Seta
Jul 4, 2019·Drug Metabolism Reviews·Rui Filipe Libânio Osório Marta
Sep 24, 2002·The Annals of Pharmacotherapy·Tony Antoniou, Alice Lin-In Tseng

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