PMID: 8595617Nov 1, 1995Paper

Effects of inflammatory cytokines on vascular tone

Cardiovascular Research
F OhkawaK Shimada

Abstract

To assess the direct effects of the inflammatory cytokines interleukin-2 (IL-2), interleukin-6 (IL-6) and interleukin-8 (IL-8) on vascular smooth muscle contraction. Smooth muscle contractility was studied in the thoracic aorta isolated from male Sprague-Dawley rats. Syntheses of cAMP and nitric oxide (NO) were investigated in cultured rat vascular smooth muscle cells (VSMC). Pretreatment of the rings with IL-6 (10 ng/ml) for 180 min caused a significant inhibition of their contraction in response to 10(-5) M phenylephrine, wile Il-2 (10 ng/ml) and IL-8 (100 ng/ml) showed no significant effect on the contraction. The inhibitory effect of IL-6 exhibited a dose-dependency (0.1 approximately 10 ng/ml). In cultured rat VSMC, synthesis of cAMP was increased time-dependently by IL-6, while IL-2 and IL-8 failed to show any significant effects. IL-2, IL-6 and IL-8 did not affect the production of nitrite, a stable metabolite of NO, by VSMC. IL-6, but not IL-2 and IL-8, is a potent inhibitor of vascular contraction, which effect is mediated through the increased cAMP synthesis.

Citations

Jul 27, 2007·Pediatric Surgery International·Toru UesugiSachiyo Suita
May 24, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Sewon LeeCuihua Zhang
Mar 18, 2011·BMC Medicine·Nele Maenhaut, Johan Van de Voorde
Jun 2, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Cherie A SingerWilliam T Gerthoffer
Feb 6, 1999·The American Journal of Gastroenterology·J GenescaJ Guardia
Mar 10, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Zhongping CaoShike Hou

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