Effects of infliximab therapy on biological markers of synovium activity and cartilage breakdown in patients with rheumatoid arthritis

Annals of the Rheumatic Diseases
H MarotteP D Delmas

Abstract

Defining the remission criteria of rheumatoid arthritis (RA) remains a critical issue. Markers of synovium activity, urinary glucosyl-galactosyl-pyridinoline (Glc-Gal-PYD) and of cartilage destruction, urinary C-terminal crosslinking telopeptide of type II collagen (CTX-II) have been shown to reflect disease activity and joint damage progression in RA. The prospective study cohort comprised 66 RA patients treated with infliximab and methotrexate and 76 healthy controls. Measurements of urinary Glc-Gal-PYD and CTX-II were performed at baseline and at 1 year of infliximab therapy. At baseline, urinary Glc-Gal-PYD and CTX-II levels were increased in patients with RA and correlated with modified Sharp scores and progression of joint damage. Patients with more progressive joint destruction had higher Glc-Gly-PYD and CTX-II baseline levels. These markers reflected bone erosion evolution and might be useful for treatment monitoring and evaluation of RA. Markers remained high even in clinical responders after infliximab, suggesting persistence of synovitis.

Citations

Nov 3, 2011·Nature Reviews. Rheumatology·Maria G Tektonidou, Michael M Ward
Sep 1, 2009·Assay and Drug Development Technologies·Anne-Christine Bay-JensenPer Qvist
Mar 7, 2009·Arthritis Research & Therapy·Ravi C DwivediHani S El-Gabalawy
Sep 24, 2009·Current Rheumatology Reports·Jackie NamPaul Emery
Jan 24, 2012·Best Practice & Research. Clinical Rheumatology·Per QvistMorten A Karsdal
Aug 25, 2010·Best Practice & Research. Clinical Rheumatology·James Dale, Duncan Porter
May 19, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Hubert Marotte, Pierre Miossec
Jan 21, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Per QvistAnne-Christine Bay-Jensen

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