Effects of Influenza on Alveolar Macrophage Viability Are Dependent on Mouse Genetic Strain

The Journal of Immunology : Official Journal of the American Association of Immunologists
D CalifanoD W Metzger

Abstract

Secondary bacterial coinfections following influenza virus pose a serious threat to human health. Therefore, it is of significant clinical relevance to understand the immunological causes of this increased susceptibility. Influenza-induced alterations in alveolar macrophages (AMs) have been shown to be a major underlying cause of the increased susceptibility to bacterial superinfection. However, the mechanisms responsible for this remain under debate, specifically in terms of whether AMs are depleted in response to influenza infection or are maintained postinfection, but with disrupted phagocytic activity. The data presented in this article resolves this issue by showing that either mechanism can differentially occur in individual mouse strains. BALB/c mice exhibited a dramatic IFN-γ-dependent reduction in levels of AMs following infection with influenza A, whereas AM levels in C57BL/6 mice were maintained throughout the course of influenza infection, although the cells displayed an altered phenotype, namely an upregulation in CD11b expression. These strain differences were observed regardless of whether infection was performed with low or high doses of influenza virus. Furthermore, infection with either the H1N1 A/California/0...Continue Reading

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Citations

Feb 13, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karl J FischerKeer Sun
Jun 12, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joshua M TobinKeven M Robinson
Jul 11, 2020·Clinical Science·Ellyse M CipollaJohn F Alcorn
Jan 9, 2019·Frontiers in Immunology·David J MorganTracy Hussell
Feb 26, 2020·The FEBS Journal·Heather S KoehlerEdward S Mocarski
Mar 3, 2020·Frontiers in Immunology·Elizabeth R Aguilera, Laurel L Lenz
Mar 11, 2020·Nature Communications·Michelle SchorerNicole Joller
Aug 17, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Atul K VermaKeer Sun
Jan 12, 2021·Nature·Rogan A GrantUNKNOWN NU SCRIPT Study Investigators
Jun 3, 2021·International Journal of Molecular Sciences·Janine J WildenYvonne Boergeling
Jul 16, 2021·The Journal of Clinical Investigation·G R Scott BudingerRichard G Wunderink
Aug 10, 2021·Frontiers in Immunology·Rainer KnollJonas Schulte-Schrepping
Nov 18, 2021·Clinical Microbiology Reviews·Fabián SalazarAdilia Warris

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