Effects of influenza vaccination on the risk of cardiovascular and respiratory diseases and all-cause mortality

Ageing Research Reviews
Yangyang ChengSean X Leng

Abstract

Influenza vaccination is a simple strategy recommended for the prevention of influenza infection and its complications. This meta-analysis aimed to provide current supportive evidence for the breadth and validity of the observed protective effects of influenza vaccination on cardiovascular and respiratory adverse outcomes and all-cause mortality in older adults and in general adult population. We searched PubMed, Embase, Web of Science, and the Cochrane Library to identify all published studies comparing influenza vaccination with placebo from the database inception to November 11, 2018. These included studies reporting the associations of influenza vaccination with the risk of aforementioned adverse outcomes. The pooled adjusted relative risks among influenza-vaccinated people relative to unvaccinated people for the outcomes of interest were 0.74 (95 % confidence interval [CI] = 0.70-0.78) for cardiovascular diseases (63 studies), 0.82 (95 % CI = 0.75-0.91) for respiratory diseases (29 studies), and 0.57 (95 % CI = 0.51-0.63) for all-cause mortality (43 studies). We performed subgroup analysis of age, sex, and region/country and found that these protective effects were evident in the general adult population and particularly r...Continue Reading

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Citations

Nov 12, 2020·Trends in Endocrinology and Metabolism : TEM·Qingyu DouPeng Jia
Oct 15, 2021·Heart·Francisco José de AbajoAlberto García-Lledó
Nov 9, 2021·PloS One·Aldiane Gomes de Macedo BacurauPriscila Maria Stolses Bergamo Francisco

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