PMID: 2509616Sep 1, 1989Paper

Effects of infusions of various doses of bovine growth hormone-releasing factor on blood hormones and metabolites in lactating Holstein cows

The Journal of Endocrinology
W J EnrightH A Tucker

Abstract

In two experiments, the effects of i.v. infusions of various doses of bovine GH-releasing factor (GRF) on blood hormones and metabolites in lactating Holstein cows were determined. In experiment 1, cows were infused with GRF (0, 3.125, 6.25, 12.5, 25.0 or 50.0 mg/cow per 24 h) for 24 h. Blood was sampled at -1, 5, 11, 15 and 23 h relative to the start of the infusion. The serum concentration of somatomedin C (SM-C) before infusion was 303 +/- 8 (S.E.M.) micrograms/l. Doses of GRF of between 3.125 and 50.0 mg were equipotent in stimulating (P less than 0.05) SM-C by 1.5- to 2.5-fold. GRF-induced increases in SM-C occurred by 11 h from the start of the infusion. In experiment 2, primiparous cows were infused with GRF (0, 1 or 3 mg/24 h) for 20 days. Blood was sampled for 12 h on days 1, 10 and 19. The 1 mg dose of GRF increased (P less than 0.05) blood concentrations of SM-C (on days 10 and 19) and glucose (on day 19), but did not affect blood concentrations of prolactin, insulin, cortisol, tri-iodothyronine (T3), thyroxine (T4), non-esterified fatty acids (NEFA) or glucose. The 3 mg dose of GRF increased (P less than 0.05) blood concentrations of SM-C (on days 10 and 19), T3 (on days 10 and 19), insulin (on day 19), NEFA (on day...Continue Reading

Citations

Jan 1, 1995·Comparative Biochemistry and Physiology. Part A, Physiology·R F Moellers, L A Cogburn
Jun 1, 2008·Animal : an International Journal of Animal Bioscience·J PattonS T Butler
May 7, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·S T ButlerW R Butler
Apr 2, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·M Mondal, B S Prakash
Nov 7, 2006·Journal of Animal Physiology and Animal Nutrition·Mohan MondalB S Prakash
Sep 4, 2018·Frontiers in Physiology·Tina NapsoAmanda N Sferruzzi-Perri
Feb 24, 2009·Journal of Chromatography. a·Irmgard RiedmaierHeinrich H D Meyer

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