PMID: 640238Mar 1, 1978Paper

Effects of ingestion of triglyceride or galactose on secretion of gastric inhibitory polypeptide and on responses to intravenous glucose in normal and diabetic subjects

Diabetes
S A Ross, J Dupre

Abstract

Responses of plasma immunoreactive gastric inhibitory polypeptide (IRGIP) to oral triglyceride or galactose were compared in normal and mildly diabetic (non-insulin-dependent) subjects. After triglyceride the responses of IRGIP were similar, but after galactose those of the diabetics were slightly exaggerated. Both stimuli evoked increments of plasma immunoreactive glucagon (IRG) in diabetics but not in normal subjects. Plasma immunoreactive insulin (IRI) did not change. In normal subjects given oral triglyceride or galactose followed by intravenous (I.V.) glucose the early-phase response of plasma IRI was enhanced and glucose tolerance improved. In the diabetics, oral triglyceride did not affect insulin release or glucose tolerance after I.V. glucose; oral galactose elicited a slight increase of insulin release without improving glucose tolerance. In the diabetics the rise of plasma IRG after ingestion of triglyceride or galactose was maintained after I.V. glucose. It is concluded that endogenous GIP is insulinotropic and that there is partial resistance to this action in diabetes. The results were compatible with feedback inhibition of GIP secretion by insulin and with the suggestion that the rise of plasma IRG associated wit...Continue Reading

Citations

Oct 1, 1984·Diabetologia·W Creutzfeldt
Nov 18, 2010·Obesity Surgery·Raghavendra S Rao, Subhash Kini
Mar 12, 2003·Trends in Pharmacological Sciences·Timothy J Kieffer
Jul 26, 2002·Regulatory Peptides·Juris J MeierBaptist Gallwitz
Sep 10, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R E WeaverA J Balmforth
Dec 17, 2008·Pharmacological Reviews·Wook Kim, Josephine M Egan
May 1, 1980·The Journal of Clinical Investigation·C A VerdonkF J Service
Jun 6, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M AsmarJ Bülow
Apr 1, 1979·Diabetologia·L M MorganV Marks
Jan 1, 1982·Acta diabetologica latina·B BeckG Debry
Aug 27, 2011·Langenbeck's Archives of Surgery·M GassR Peterli
Sep 15, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Nigel Irwin, Peter R Flatt
May 4, 2004·Annales d'endocrinologie·T J Kieffer
Dec 1, 1982·European Journal of Clinical Investigation·D L SarsonS R Bloom
Dec 21, 2011·Physiology & Behavior·Eleftheria DiakogiannakiFrank Reimann
Jul 15, 2009·Trends in Endocrinology and Metabolism : TEM·Rhonda D Wideman, Timothy J Kieffer
Jul 24, 2010·Diabetes, Obesity & Metabolism·I A MontgomeryP R Flatt
Jan 1, 1987·Diabetes/metabolism Reviews·R Ebert, W Creutzfeldt
Feb 1, 1993·Diabetes Research and Clinical Practice·M J Alam, K D Buchanan
Mar 1, 1983·Metabolism: Clinical and Experimental·C A WilliamsI Macdonald
Mar 23, 2005·Regulatory Peptides·Tanya Hansotia, Daniel J Drucker
Jun 1, 1988·Journal of the American College of Nutrition·C K LardinoisE L Mazzaferri
Aug 1, 1985·Diabetologia·W Creutzfeldt, R Ebert
Jul 12, 2005·Expert Opinion on Investigational Drugs·Octaviano A RogesAthena Philis-Tsimikas
Dec 10, 2009·American Journal of Physiology. Endocrinology and Metabolism·Meena AsmarJens Juul Holst
Apr 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·P H GroopL C Groop
Oct 1, 2014·Molecular Endocrinology·Cesar A Sommer, Gustavo Mostoslavsky

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