Effects of inhalation exposure to a high-boiling (288 to 454 degrees C) coal liquid

Toxicology and Applied Pharmacology
D L SpringerD D Mahlum

Abstract

Coal liquids have been evaluated in a variety of short-term toxicological assays; however, few studies have been conducted to determine the systemic effects after inhalation exposure to these materials. To extend the data base on potential health effects from coal liquefaction materials, we performed a study with solvent refined coal (SRC)-II heavy distillate (HD). Fischer-344 rats were exposed for 6 hr/day, 5 days/week for 5 or 13 weeks to an aerosol of HD (boiling range, 288 to 454 degrees C) at concentrations of 0.69, 0.14, 0.03, or 0.0 mg/liter of air for the high, middle, low, and control groups, respectively. Survival through 13 weeks of exposure was greater than 90% for all groups; body weights for exposed animals were decreased in a dose-dependent manner. Significant increases in liver weights and decreases in thymus and ovary weights were observed for treated animals compared with controls. There were also significant treatment-related decreases in erythrocytes, hemoglobin, volume of packed red blood cells, lymphocytes, eosinophils, and total white blood cells. After 5 weeks of exposure serum cholesterol concentrations increased in a dose-dependent manner for both sexes and serum triglyceride amounts decreased for male...Continue Reading

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Citations

Dec 1, 1990·Journal of Applied Toxicology : JAT·I ChuP Beyrouty
Jul 1, 1994·Journal of Applied Toxicology : JAT·L ChuC G Rousseaux
Jan 1, 1988·Journal of Toxicology and Environmental Health·I ChuR Otson
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Sep 26, 2007·Journal of Medical Case Reports·Thomas F HiemstraJeremy H Hughes
Mar 1, 1988·Bulletin of Environmental Contamination and Toxicology·A YagminasD C Villeneuve
Nov 1, 2004·Environmental Toxicology and Pharmacology·Raymond S H YangMoiz Mumtaz
Feb 1, 1989·Journal of Applied Toxicology : JAT·L B SasserD D Mahlum

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