Effects of inhaled beclomethasone dipropionate on respiratory function in horses with chronic obstructive pulmonary disease (COPD)

Equine Veterinary Journal
V J AmmannJ P Lavoie

Abstract

The effects of beclomethasone dipropionate on pulmonary function and arterial blood gas values were investigated in horses with chronic obstructive pulmonary disease (COPD). Six mature mares, diagnosed as having COPD based on clinical signs, cytological examination of bronchoalveolar lavage and pulmonary function testing, were used. Beclomethasone dipropionate (3750 microg) was administered b.i.d. for a 2 week period with a metered dose inhaler using a mask. Pulmonary function tests and arterial blood gas analyses were performed at weekly intervals, starting before beclomethasone administration and for 4 weeks thereafter. Upper airway endoscopy and nasopharyngeal fungal cultures were performed before and after treatment. Maximal variations in transpulmonary pressure (deltaPL) were elevated in all horses at baseline. Beclomethasone administration resulted in a significant decrease in deltaPL in 5 horses, and deltaPL fell to within the normal range in 4 horses. Two weeks after the end of treatment, deltaPL was at or above baseline values in all horses. Total pulmonary resistance and elastance decreased significantly during treatment and returned to or above baseline values after the administration of beclomethasone was discontinu...Continue Reading

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Citations

Aug 10, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mathilde LeclereJean-Pierre Lavoie
Apr 15, 2011·Journal of Veterinary Internal Medicine·J DauvillierJ-P Lavoie
Oct 12, 2010·American Journal of Respiratory Cell and Molecular Biology·Mathilde LeclereJean-Pierre Lavoie
Jan 26, 2016·Journal of Veterinary Internal Medicine·L L CouëtilE A Richard
Jul 10, 2007·The Veterinary Clinics of North America. Equine Practice·Katherine K Williamson, Michael S Davis
Aug 29, 2007·Equine Veterinary Journal·D L Evans
Oct 30, 2013·Equine Veterinary Journal·R S Pirie
Jan 9, 2003·The Veterinary Clinics of North America. Equine Practice·Elizabeth Davis, Bonnie R Rush
May 16, 2003·The Veterinary Clinics of North America. Equine Practice·Renaud Léguillette
May 9, 2009·Acta Veterinaria Scandinavica·Görel NymanGöran Hedenstierna
Mar 16, 2017·Equine Veterinary Journal·L CalzettaM G Matera
Sep 12, 2018·Equine Veterinary Journal·J P LavoieB Albrecht
Oct 21, 2004·The Veterinary Record·T T J M LaanJ Fink-Gremmels
Jan 31, 2002·Equine Veterinary Journal·N E RobinsonF J Derksen
Jul 16, 2004·Equine Veterinary Journal·C J CornelisseF J Derksen
Jun 5, 2021·Journal of Veterinary Internal Medicine·Sophie Mainguy-Seers, Jean-Pierre Lavoie
Sep 2, 2021·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·Ann Kristin Barton, Heidrun Gehlen

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