Effects of inhaled corticosteroids on systemic blood pressure in preterm infants

Biology of the Neonate
P C NgE Wong

Abstract

To assess the effect of inhaled fluticasone propionate on (i) systemic blood pressure, and (ii) the need for volume expanders (crystalloids and colloids) and inotropes for blood pressure support in preterm, very low birth weight (VLBW) infants. Ventilated VLBW infants, less than 32 weeks of gestation, with respiratory distress syndrome were randomised to receive a 14-day course of either fluticasone propionate (500 microg/puff, 2 puffs every 12 h; n=27) or placebo (n=26) with a metered dose inhaler-spacer device. The response of treatment was assessed by comparing the use of volume expanders, inotropes, and the average and the lowest systolic, mean and diastolic blood pressures in 6 hourly epochs between the 2 groups. There were no significant differences in the average or the lowest systolic, mean and diastolic blood pressures in 6 hourly epochs between the 2 groups. However, the total volume of crystalloids and colloids requirement was significantly greater in control than in treated infants (p=0.03). There was also a trend towards greater consumption of the total cumulative dose of dopamine in the control infants (p=0.10). Fluticasone-treated infants required significantly less volume of crystalloids and colloids for blood p...Continue Reading

Citations

Sep 8, 2016·Archives of Disease in Childhood. Fetal and Neonatal Edition·Pak Cheung Ng
Dec 14, 2011·The Cochrane Database of Systematic Reviews·Hafis IbrahimNimish V Subhedar

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