Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group

Critical Care Medicine
R P DellingerP Papadakos

Abstract

To evaluate the safety and physiologic response of inhaled nitric oxide (NO) in patients with acute respiratory distress syndrome (ARDS). In addition, the effect of various doses of inhaled NO on clinical outcome parameters was assessed. Prospective, multicenter, randomized, double-blind, placebo-controlled study. Intensive care units of 30 academic, teaching, and community hospitals in the United States. Patients with ARDS, as defined by the American-European Consensus Conference, were enrolled into the study if the onset of disease was within 72 hrs of randomization. Patients were randomized to receive placebo (nitrogen gas) or inhaled NO at concentrations of 1.25, 5, 20, 40, or 80 ppm. Acute increases in PaO2, decreases in mean pulmonary arterial pressure, intensity of mechanical ventilation, and oxygenation index were examined. Clinical outcomes examined were the dose effects of inhaled NO on mortality, the number of days alive and off mechanical ventilation, and the number of days alive after meeting oxygenation criteria for extubation. A total of 177 patients were enrolled over a 14-month period. An acute response to treatment gas, defined as a PaO2 increase > or =20%, was seen in 60% of the patients receiving inhaled NO ...Continue Reading

References

Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Jan 1, 1993·Advances in Experimental Medicine and Biology·M W Radomski, S Moncada
Nov 17, 1994·Annals of the New York Academy of Sciences·D A WinkJ B Mitchell
Aug 1, 1994·Respiration Physiology·Y KatayamaM Kitabatake
Feb 11, 1993·The New England Journal of Medicine·R RossaintW M Zapol
Feb 1, 1993·Circulation·J D RobertsW M Zapol
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·S Chollet-MartinD M Payen
May 23, 1957·The Journal of Physiology·W H GIBSON, F J ROUGHTON

❮ Previous
Next ❯

Citations

Feb 28, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Fred J BaxterPeter T-L Choi
May 15, 2004·Current Infectious Disease Reports·Gavin M. Joynt, H. Y. Yap
Feb 23, 2002·Current Treatment Options in Cardiovascular Medicine·Michael A. MatthayXiaohui Fang
Feb 24, 2001·The Annals of Thoracic Surgery·J B ZwischenbergerA Bidani
Feb 4, 1999·The Annals of Thoracic Surgery·D J MathisenC D Wright
Feb 9, 2000·Pharmacology & Therapeutics·B WeinbergerJ D Laskin
Oct 6, 2000·Clinics in Chest Medicine·R G Brower, H E Fessler
Feb 13, 2001·Resuscitation·P A OakleyP J Morrison
Jul 19, 2002·Chest Surgery Clinics of North America·Steven A Conrad, Akhil Bidani
Apr 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·E J BirksM H Yacoub
Dec 21, 2000·British Journal of Haematology·C R MorrisL A Styles
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Dec 24, 2005·The New England Journal of Medicine·Mark J D Griffiths, Timothy W Evans
Nov 17, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Luni ChenChen G Wang
Jan 9, 2008·Antioxidants & Redox Signaling·Sadatomo TasakaAkitoshi Ishizaka
Jan 16, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Elizabeth R Johnson, Michael A Matthay
Jan 15, 1998·Critical Care Medicine·M A MatthayC Jayr
Mar 21, 1998·Critical Care Medicine·R P DellingerR C Straube
Feb 6, 1999·Critical Care Medicine·J H Arnold
Jul 9, 1999·Critical Care Medicine·P G Smith, J Blumer
Oct 3, 1999·Critical Care Medicine·L M Bigatello, W E Hurford
Dec 1, 1999·Critical Care Medicine·G VoggenreiterK P Schmit-Neuerburg
Feb 7, 2001·Critical Care Medicine·I M Cheifetz
May 16, 2000·Critical Care Medicine·Z M Quezado, P Q Eichacker
Aug 31, 2000·Critical Care Medicine·Y G Weiss, C S Deutschman
Sep 29, 2000·Critical Care Medicine·R C McIntyreE Abraham
Apr 10, 2002·Critical Care Medicine·Habib M RazaviSanjay Mehta
Jun 1, 1999·Current Opinion in Pediatrics·M R Hemmila, R B Hirschl
Jul 20, 2002·Current Opinion in Pediatrics·Ronald B Hirschl
Feb 13, 2003·Current Opinion in Hematology·Christopher D Reiter, Mark T Gladwin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.