Effects of inhaled therapy on biomarkers of systemic inflammation in stable chronic obstructive pulmonary disease

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Sabina A Antoniu

Abstract

In chronic obstructive pulmonary disease (COPD) airways inflammation is associated in more advanced stages with systemic inflammation. COPD-associated systemic inflammation syndrome is defined currently with rather non-specific biomarkers such as C-reactive protein (CRP) but there are also other 'organ-specific' biomarkers such as surfactant protein-D which are still not well characterized but might represent more appropriate and reliable alternatives to the non-specific biomarkers. Inhaled therapies are the mainstay in stable COPD and they were demonstrated to reduce airway inflammation and more recently in the case of inhaled corticosteroids alone or combined with long-acting beta-2 agonists to reduce systemic inflammation as well. This paper focuses on current and potential biomarkers of systemic inflammation in COPD and on the systemic anti-inflammatory effects of inhaled therapies in stable COPD.

References

Nov 1, 1994·American Journal of Respiratory and Critical Care Medicine·M Di FranciaJ Orehek
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·Y HondaS Abe
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·I de GodoyR M Rogers
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·V M KeatingsP J Barnes
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·P W Jones, T K Bosh
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·P B BoltonD M McDonald
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·M DahlB G Nordestgaard
Feb 28, 2002·The European Respiratory Journal·R CasaburiT Witek
Mar 2, 2002·The European Respiratory Journal·W VinckenUNKNOWN Dutch/Belgian Tiotropium Study Group
Jun 19, 2002·American Journal of Respiratory and Critical Care Medicine·Keith L HattotuwaNeil C Barnes
Feb 14, 2003·Lancet·Peter CalverleyUNKNOWN TRial of Inhaled STeroids ANd long-acting beta2 agonists study group
May 30, 2003·The Biochemical Journal·Peter C HeinrichFred Schaper
Jul 23, 2003·American Journal of Respiratory Cell and Molecular Biology·Elena N AtochinaAndrew J Gow
Aug 19, 2003·The Annals of Pharmacotherapy·John A DoughertyLoutfi S Aboussouan
Nov 19, 2003·The European Respiratory Journal. Supplement·P M A Calverley
Dec 19, 2003·The European Respiratory Journal·P M CalverleyH Olsson
Jun 16, 2004·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Cedric HermansIan R Doyle
Jul 2, 2004·American Journal of Respiratory and Critical Care Medicine·Don D SinS F Paul Man
Jan 21, 2006·American Journal of Respiratory and Critical Care Medicine·Neil C BarnesUNKNOWN SCO30005 Study Group
Oct 13, 2006·Respiratory Research·Srirupa MukhopadhyayTapan K Mukherjee
Oct 21, 2006·American Journal of Respiratory and Critical Care Medicine·Morten DahlBørge G Nordestgaard
Apr 12, 2007·Expert Opinion on Pharmacotherapy·Sabina A AntoniuClaudio F Donner
May 17, 2007·The European Respiratory Journal·D J PowrieJ A Wedzicha
Jul 13, 2007·Respiratory Medicine·Fulvio BraidoGiorgio Walter Canonica
Aug 1, 2007·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Rachel GarrodGerry Hagan
Feb 5, 2008·European Journal of Pharmacology·Mirella ProfitaMark Gjomarkaj
Mar 4, 2008·American Journal of Respiratory and Critical Care Medicine·Don D SinUNKNOWN ABC (Advair, Biomarkers in COPD) Investigators

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Citations

Nov 29, 2013·Drug Design, Development and Therapy·Annette J TheronRonald Anderson
May 14, 2011·The American Journal of Geriatric Pharmacotherapy·David R Thomas
Dec 22, 2015·Multidisciplinary Respiratory Medicine·Andréa Lúcia Gonçalves da SilvaLia Gonçalves Possuelo
Sep 7, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Andrew J Ghio
Mar 10, 2015·Chronic Respiratory Disease·Sabina Antonela Antoniu, Didona Ungureanu

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