PMID: 9163651May 1, 1997Paper

Effects of inhaled versus intravenous vasodilators in experimental pulmonary hypertension

The European Respiratory Journal
D WalmrathWerner Seeger

Abstract

Inhaled nitric oxide (NO) causes selective pulmonary vasodilation and improves gas exchange in acute lung failure. In experimental pulmonary hypertension, we compared the influence of the aerosolized vasodilatory prostaglandins (PG) PGI2 and PGE1 on vascular tone and gas exchange to that of infused prostanoids (PGI2, PGE1) and inhaled NO. An increase of pulmonary artery pressure (Ppa) from 8 to approximately 34 mmHg was provoked by continuous infusion of U-46619 (thromboxane A2 (TxA2) analogue) in blood-free perfused rabbit lungs. This was accompanied by formation of moderate lung oedema and severe ventilation-perfusion (V'/Q') mismatch, with predominance of shunt flow (>50%, assessed by the multiple inert gas elimination technique). When standardized to reduce the Pps by approximately 10 mmHg, inhaled NO (200 ppm), aerosolized PGI2 (4 ng x kg(-1) x min(-1)) and nebulized PGE1 (8 ng x kg(-1) x min(-1)) all reduced both pre- and postcapillary vascular resistance, but did not affect formation of lung oedema. All inhalative agents improved the V'/Q' mismatch and reduced shunt flow, the rank order of this capacity being NO > PGI2 > PGE1. In contrast, lowering of Ppa by intravascular administration of PGI2 and PGE1 did not improve g...Continue Reading

Citations

Oct 16, 1999·General Pharmacology·J P DumasM Dumas
Oct 13, 2006·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Ralph Theo SchermulyWerner Seeger
Nov 24, 1999·Thorax·A J Peacock
Aug 19, 1999·Thorax·S Brij, A J Peacock
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·G HermleF Grimminger
May 10, 2008·Journal of Medical Case Reports·Shahla Siddiqui, Naveed Latif
Oct 29, 2008·Critical Care : the Official Journal of the Critical Care Forum·Sebastien TrachselGöran Hedenstierna
Apr 9, 2008·Pediatric Research·Beena G SoodE M Haacke
May 14, 2009·Vascular Health and Risk Management·Cecile Tissot, Maurice Beghetti
May 16, 2014·Annals of the American Thoracic Society·Corey E Ventetuolo, James R Klinger
Jul 6, 2014·Critical Care Clinics·Christopher KingOksana A Shlobin
Sep 27, 2012·Progress in Cardiovascular Diseases·Hooman D Poor, Corey E Ventetuolo
Sep 27, 2012·Progress in Cardiovascular Diseases·Hooman D PoorSean M Studer
Aug 4, 2009·Pulmonary Pharmacology & Therapeutics·Hanno H LeuchteJürgen Behr
Aug 19, 2009·Prostaglandins & Other Lipid Mediators·Beena G SoodRaja Rabah
Jul 29, 2008·Pulmonary Pharmacology & Therapeutics·Robert VoswinckelHossein A Ghofrani
Mar 18, 2008·Pulmonary Pharmacology & Therapeutics·Beena G SoodRaja Rabah
Nov 17, 2007·International Journal of Cardiology·Zek S LimGruschen R Veldtman
Aug 30, 2006·Acta Paediatrica·Beena G SoodSeetha Shankaran
Oct 26, 2012·Anesthesiology Research and Practice·Jochen GilleArmin Sablotzki
Dec 17, 2014·Trials·Beena G SoodUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Jul 24, 2007·Respiratory Medicine·Norbert WeissmannFriedrich Grimminger
Aug 2, 2001·The Journal of Thoracic and Cardiovascular Surgery·D C StuesseD D Trunkey
Nov 6, 2007·International Journal of Pharmaceutics·Kerstin LahnsteinTobias Gessler
Sep 21, 2016·Chest·Kimberly J Dunham-SnaryStephen L Archer
Aug 10, 2002·Anesthesiology·Stuart M Lowson
Apr 28, 2005·Expert Review of Cardiovascular Therapy·Hanno H Leuchte, Jürgen Behr
Feb 26, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hanno H LeuchteJürgen Behr
Jan 18, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hanno H LeuchteJürgen Behr
Oct 3, 2006·Current Opinion in Anaesthesiology·J Meyer, M Booke
Oct 5, 2006·Current Opinion in Anaesthesiology·Eleni Mouloudi, Dimitris Georgopoulos
Nov 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·R T SchermulyD Walmrath
Nov 2, 2011·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Paulo Francisco Guerreiro CardosoFabio Biscegli Jatene

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