Effects of inhibition of serotonin synthesis on 5-hydroxyindoleacetic acid excretion, in healthy subjects

Journal of Clinical Pharmacology
A B Alfieri, L X Cubeddu

Abstract

The urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA), the main metabolite of serotonin, reflects the content and turnover of gastrointestinal (GI) serotonin. Employing longitudinal measurements of 5-HIAA, the authors investigated in healthy subjects (n = 43) how manipulations of serotonin synthesis affect GI serotonin. Under conditions of serotonin-free diets, the intersubject and intrasubject variability (coefficient of variation) for 5-HIAA excretion averaged 33% and 14%, respectively. Dietary tryptophan restrictions to 50% of minimal daily requirements (which is equivalent to a 10-fold reduction in baseline tryptophan intake) decreased by half the urinary excretion of 5-HIAA, irrespective of the caloric content of diet. Restoration to the regular tryptophan intake produced a rapid normalization of the 5-HIAA excretion. Neutral amino acids are known to compete with the intestinal transport absorption mechanisms of tryptophan. Administration of neutral amino acids (1.8 g, by mouth, three times a day, before each meal) or of carbidopa (50 mg, by mouth, three times a day for 3 days) to a normal tryptophan diet failed to alter significantly the 5-HIAA excretion. Further, neutral amino acids failed to enhance the reduction...Continue Reading

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Citations

Sep 1, 1995·Amino Acids·W HeineK D Wutzke
Nov 23, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Michael Jason BishopJames A Bralley
Jan 7, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·R A PirkerM M Müller
Sep 1, 2005·Environmental Management·Douglas J BruggemanKim T Scribner
Nov 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D N D'SouzaL D Van de Kar
Jun 24, 2003·Biochemical Pharmacology·Elena B C LlambíasLeonor C San Martín de Viale

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