Effects of inhibitions of thromboxane synthesis on reactions of the cat bronchus in situ to prostaglandins

Prostaglandins
H Frey, C Dengjel

Abstract

Cats were anesthetized by chloralose, relaxed by suxamethonium, and ventilated. The influence of 3 inhibitors of thromboxane synthesis, N.0096 (+-alpha -benzyl-alpha-p-chlorobenzyl-4-hydroxyacetophenon phenylhydrogen-phosphonate), imidazole and dipyridamole were studied on bronchial reaction to prostaglandins E2 and F2 alpha and arachidonic acid. During a bronchoconstriction maintained by infusion of 5-HT, N.0096 and imidazole dose-dependently potentiated the intensity and duration of the bronchodilator effect of PGE2. This effect was maximal at a total dose of 17 mg/kg N.0096 or 25-50 mg/kg imidazole, but decreased after higher doses which are supposed to inhibit cyclo-oxygenase also. Bronchoconstrictor reactions to single injections of arachidonic acid were inhibited by N.0096 in the same dose range. Reactions to PGF2 alpha were unaltered by both drugs. Dipyridamole was devoid of a comparable activity.

References

Oct 14, 1978·Lancet·L C BestD S Segal
Sep 1, 1977·Prostaglandins·J SvenssenM Hamberg
Dec 1, 1976·European Journal of Pharmacology·H H Frey, C Dengjel
Feb 1, 1975·Life Sciences·M HambergB Samuelsson
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M Hamberg, B Samuelsson
Jan 6, 1968·Nature·W J Sweatman, H O Collier
Dec 1, 1974·European Journal of Pharmacology·H H Frey, A Schäfer
Jan 27, 1973·British Medical Journal·A A MathéN Svanborg
Jan 1, 1980·British Journal of Pharmacology·K E BlassK Pönicke

Related Concepts

alpha-benzyl-alpha-p-chlorobenzyl-4-hydroxyacetophenon phenyl-hydrogenphosphonate
Acetophenones
Metazoa
Lobar Bronchus Structure
Broncholytic Effect
Felis catus
Novo-Dipiradol
Dose-Response Relationship, Drug
Imidazoles
Prostaglandins E

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.