Effects of inhibitions of thromboxane synthesis on reactions of the cat bronchus in situ to prostaglandins

H Frey, C Dengjel


Cats were anesthetized by chloralose, relaxed by suxamethonium, and ventilated. The influence of 3 inhibitors of thromboxane synthesis, N.0096 (+-alpha -benzyl-alpha-p-chlorobenzyl-4-hydroxyacetophenon phenylhydrogen-phosphonate), imidazole and dipyridamole were studied on bronchial reaction to prostaglandins E2 and F2 alpha and arachidonic acid. During a bronchoconstriction maintained by infusion of 5-HT, N.0096 and imidazole dose-dependently potentiated the intensity and duration of the bronchodilator effect of PGE2. This effect was maximal at a total dose of 17 mg/kg N.0096 or 25-50 mg/kg imidazole, but decreased after higher doses which are supposed to inhibit cyclo-oxygenase also. Bronchoconstrictor reactions to single injections of arachidonic acid were inhibited by N.0096 in the same dose range. Reactions to PGF2 alpha were unaltered by both drugs. Dipyridamole was devoid of a comparable activity.


Oct 14, 1978·Lancet·L C BestD S Segal
Sep 1, 1977·Prostaglandins·J SvenssenM Hamberg
Dec 1, 1976·European Journal of Pharmacology·H H Frey, C Dengjel
Feb 1, 1975·Life Sciences·M HambergB Samuelsson
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M Hamberg, B Samuelsson
Jan 6, 1968·Nature·W J Sweatman, H O Collier
Dec 1, 1974·European Journal of Pharmacology·H H Frey, A Schäfer
Jan 27, 1973·British Medical Journal·A A MathéN Svanborg
Jan 1, 1980·British Journal of Pharmacology·K E BlassK Pönicke

Related Concepts

alpha-benzyl-alpha-p-chlorobenzyl-4-hydroxyacetophenon phenyl-hydrogenphosphonate
Lobar Bronchus Structure
Broncholytic Effect
Felis catus
Dose-Response Relationship, Drug
Prostaglandins E

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