PMID: 3096408Oct 1, 1986Paper

Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration

British Journal of Pharmacology
J L Wallace, B J Whittle

Abstract

The effects of several inhibitors of arachidonic acid metabolism on gastric necrosis, hypotension, haemoconcentration, leukopenia and plasma exudation induced by platelet-activating factor (Paf) were studied in the rat. A 10 min intravenous infusion of Paf (100 ng kg-1 min-1) caused extensive gastric damage and a marked fall in systemic blood pressure which had not recovered to basal levels 30 min after the infusion had been terminated. Paf also caused significant haemoconcentration, plasma exudation and transient leukopenia. Pretreatment with dexamethasone (0.2 or 2 mg kg-1 s.c.) or prednisolone (20 mg kg-1 s.c.) two hours before Paf significantly reduced the gastric damage and accelerated the recovery of blood pressure after the Paf infusion. Likewise, BW755C (50 mg kg-1 p.o.) significantly reduced the gastric damage. Acute pretreatment with dexamethasone (2 mg kg-1 i.v.) 15 min before Paf, or with indomethacin (5 mg kg-1 s.c.), acetylsalicylic acid (10 mg kg-1 i.v.) or 1-benzylimidazole (50 mg kg-1 s.c.) did not significantly affect the gastric damage induced by Paf. The Paf-induced haemoconcentration and plasma exudation were significantly reduced by pretreatment with prednisolone (20 mg kg-1 s.c.) or BW755C (50 mg kg-1 p.o...Continue Reading

References

Feb 1, 1986·Prostaglandins·B A PeskarB M Peskar
Sep 10, 1985·European Journal of Pharmacology·J L Wallace, B J Whittle
Jan 1, 1986·Agents and Actions·L ParenteG De Nucci
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S E DahlénB Samuelsson
Oct 15, 1984·European Journal of Pharmacology·P IñarreaM S Crespo
Jun 15, 1984·European Journal of Pharmacology·D V McGivern, G S Basran
Jun 1, 1983·British Journal of Pharmacology·A MyersP Ramwell
Jan 1, 1981·Annals of the New York Academy of Sciences·B B VargaftigF Wal

Citations

Feb 1, 1988·Digestive Diseases and Sciences·J L Wallace, B J Whittle
Jan 1, 1992·Agents and Actions·N K Boughton-SmithB J Whittle
Jun 22, 1988·European Journal of Pharmacology·J L Wallace, W K MacNaughton
May 19, 1989·European Journal of Pharmacology·S J KonturekG Beck
Jan 1, 1992·Free Radical Biology & Medicine·A van der Vliet, A Bast
Dec 3, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhili XuAndrew P Byrnes
Oct 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G EscolarO Bulbena
Nov 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J SugataniK Saito
Jan 1, 1988·British Journal of Pharmacology·J V Esplugues, B J Whittle
Nov 24, 1999·Journal of Neurophysiology·N OzakiG F Gebhart
Nov 1, 1996·The Journal of Pharmacy and Pharmacology·A A Izzo

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