PMID: 6982887Sep 1, 1982Paper

Effects of inhibitors of radiation-induced potentially lethal damage repair on chemotherapy in murine tumors

International Journal of Radiation Oncology, Biology, Physics
S Nakatsugawa, T Sugahara

Abstract

Enhancement of various antitumor drugs effects by inhibitors of radiation-induced potentially lethal damage (PLD) repair was studied in three murine tumors (EMT-6, RIF-1 and SQ-1). In EMT-6 tumors, PLD repair inhibitors, 3'-deoxyguanosine (3'-dG) and 7904 (a derivative of 3'-deoxyadenosine) showed a marked enhancement of tumor growth inhibition by anticancerous drugs (FT-207 (a derivative of 5-FU), bleomycin, Ara-C, ACNU). However, the effects of mitomycin-C and vincristine were not potentiated by the inhibitors. In SQ-1 carcinomas, another repair inhibitor, ara-A (1-beta-D-arabinofuranosyladenine) (32 mg/kg) potentiated the effect of ACNU. In RIF-1 sarcomas, in which a low PLD repair function has been reported after ionizing radiation exposure, the potentiation was not so marked as in EMT-6 or SQ-1 tumors. Thus, as a possibility, the potentiation by inhibitors of radiation-induced PLD repair might be a result of the inhibition of chemical-induced PLD repair. The study of this field may contribute to the improvement of cancer treatment not only by radiotherapy but also by chemotherapy.

References

Mar 1, 1982·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S NakatsugawaA Kumar
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·M R HorsmanS L Schelley

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Citations

Feb 28, 1983·Biochemical and Biophysical Research Communications·S ShinoharaT Aoyama
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·S Nakatsugawa, W C Dewey

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