PMID: 3081474Jan 1, 1986

Effects of inoculum size on the activity of carboxy- and ureido-penicillins and effects of combinations of ureido-penicillins with aminoglycosides against resistant Pseudomonas aeruginosa

The Journal of Antimicrobial Chemotherapy
C Watanakunakorn

Abstract

Effects of inoculum size on the comparative activity of carbenicillin, ticarcillin, mezlocillin, piperacillin and azlocillin against 20 strains of Pseudomonas aeruginosa known to be relatively resistant to carbenicillin were studied by using 10(4), 10(5) and 10(6) cfu/ml. Inoculum size markedly affected the susceptibility of Ps. aeruginosa to these antibiotics. An increase in the inoculum size from 10(4) to 10(5) cfu/ml had more effects on the MIC of the ureido-penicillins than the carboxy-penicillins. Mezlocillin, piperacillin and azlocillin with gentamicin or tobramycin showed mainly indifference. Synergism or antagonism were demonstrated against a few strains.

Citations

Feb 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I OdenholtO Cars
Jun 1, 1994·Antimicrobial Agents and Chemotherapy·M M McFarlandA Li Wan Po
Jul 15, 2003·Clinical Microbiology Reviews·S Vakulenko, S Mobashery

Related Concepts

Azlin
Pyopen
Dose-Response Relationship, Drug
Drug Combinations
Gentacycol
Melocin
Fungus Drug Sensitivity Tests
Penicillin Resistance
Penicillin
Piperacillin-ratiopharm

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.