Effects of inorganic arsenic on the rat and mouse urinary bladder

Toxicological Sciences : an Official Journal of the Society of Toxicology
Shugo SuzukiSamuel M Cohen

Abstract

Inorganic arsenic (arsenate and arsenite) is a known human carcinogen, inducing tumors of the skin, urinary bladder, and lung. Understanding the mechanism of inorganic arsenic carcinogenesis has been hampered by a lack of animal models. To define the urothelial effects of inorganic arsenic, we administered arsenate and arsenite in the diet or drinking water to rats and mice in several short-term experiments (2-10 weeks). Treatment with arsenate or arsenite in the drinking water or diet induced cytotoxicity and necrosis of the urothelial superficial layer and hyperplasia in rats and mice. Arsenate-induced changes occurred later in mice compared with arsenite-induced changes, but not in the rat. Hyperplasia in rats was evident by light microscopy at an earlier time point (2 weeks) than previously observed after treatment with dimethylarsinic acid (DMA(V)). The bromodeoxyuridine labeling index was increased in treated rats. We were unable to determine the bromodeoxyuridine labeling index in mice. The effects of inorganic arsenicals on the bladder were greater when administered in the drinking water than in the diet in rats and mice, but so was the overall toxicity to the animal. The female rat appeared more sensitive to the effect...Continue Reading

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Citations

Apr 23, 2013·Archives of Environmental Contamination and Toxicology·Jo Ellen HinckDonald E Tillitt
Apr 30, 2013·Histochemistry and Cell Biology·E J Grasso, R O Calderón
Jun 6, 2013·Chemical Research in Toxicology·Baowei ChenX Chris Le
Mar 10, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Masanao YokohiraSamuel M Cohen
Jul 29, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·H J ClewellJ W Yager
Oct 8, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Puttappa R DodmaneSamuel M Cohen
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Nov 19, 2019·BioMed Research International·Cesar Rivas-SantiagoYamilé López-Hernández
Nov 27, 2020·Journal of Toxicologic Pathology·Shugo SuzukiHideki Wanibuchi

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