PMID: 16501729Feb 28, 2006Paper

Effects of insecticide-treated bednets during early infancy in an African area of intense malaria transmission: a randomized controlled trial

Bulletin of the World Health Organization
O MüllerHeiko Becher

Abstract

Insecticide-impregnated bednets and curtains have been shown by many studies to be effective against malaria. However, because of possible interactions with immunity development, treated bednets may cause no effect at all or even an increase in malaria morbidity and mortality in areas of high transmission. To clarify this issue, we did a randomized controlled trial to assess the long-term effects of bednet protection during early infancy. A total of 3387 neonates from 41 villages in rural Burkina Faso were individually randomized to receive either bednet protection from birth (group A) or from age 6 months (group B). Primary outcomes were all-cause mortality in all study children and incidence of falciparum malaria in a representative subsample of the study population. After a mean follow-up of 27 months, there were 129 deaths in group A and 128 deaths in group B rate ratio (RR) 1.0 (95% confidence interval (CI): 0.78-1.27)). Falciparum malaria incidence was lower in group A than in group B, during early (0-5 months) and late infancy (6-12 months) (RR 3.1, 95% CI: 2.0-4.9; RR 1.3, 95% CI: 1.1-1.6) and rates of moderate to severe anaemia were significantly lower during late infancy (11.5% vs 23.3%, P = 0.008), but there were no ...Continue Reading

Citations

Mar 10, 2010·Journal of Tropical Pediatrics·S S YamamotoR Sauerborn
Apr 28, 2010·Indian Journal of Pediatrics·Shiv LalV K Saxena
Mar 28, 2012·Global Health Action·Annelies Wilder-SmithDuane Gubler
Nov 20, 2012·Journal of Dietary Supplements·Catherine UlbrichtSara Zhou
Jun 10, 2014·Frontiers in Pharmacology·Natasha SpottiswoodeHal Drakesmith
Sep 6, 2012·BMC Public Health·Abdoulaye Hama DialloUNKNOWN PROMISE-EBF Study Group
Dec 16, 2006·International Journal of Epidemiology·Robert Peter NdugwaHeribert Ramroth
Jun 13, 2012·The International Journal of Health Planning and Management·Manuela De AllegriOlaf Mueller
Jul 19, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Caroline E WhiddenS Deepika Fernando
Aug 16, 2006·Malaria Journal·Claudia FreyOlaf Müller

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