PMID: 2501281May 1, 1989Paper

Effects of inspiratory resistive load on respiratory control in hypercapnia and exercise

Journal of Applied Physiology
C S Poon

Abstract

Eight healthy young men underwent two separate steady-state incremental exercise runs within the aerobic range on a treadmill with alternating periods of breathing with no load (NL) and with an inspiratory resistive load (IRL) of approximately 12 cmH2O.1-1.s. End-tidal PCO2 was maintained constant throughout each run at the eucapnic or a constant hypercapnic level by adding 0-5% CO2 to the inspired O2. Hypercapnia caused a steepening, as well as upward shift, relative to the corresponding eucapnic ventilation-CO2 output (VE - VCO2) relationship in NL and IRL. Compared with NL, the VE - VCO2 slope was depressed by IRL, more so in hypercapnic [-19.0 +/- 3.4 (SE) %] than in eucapnic exercise (-6.0 +/- 2.0%), despite a similar increase in the slope of the occlusion pressure at 100 ms - VCO2 (P100 - VCO2) relationship under both conditions. The steady-state hypercapnic ventilatory response at rest was markedly depressed by IRL (-22.6 +/- 7.5%), with little increase in P100 response. For a given inspiratory load, breathing pattern responses to separate or combined hypercapnia and exercise were similar. During IRL, VE was achieved by a greater tidal volume (VT) and inspiratory duty cycle (TI/TT) along with a lower mean inspiratory flo...Continue Reading

Citations

Mar 1, 1992·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·M J Del Volgo, M C Noel-Jorand
Jan 1, 1991·Annals of Biomedical Engineering·Y OkuN S Cherniack
Apr 1, 1996·Medicine and Science in Sports and Exercise·T BussoA Geyssant
Jan 18, 2003·Journal of Applied Physiology·T G BabbBrenda L Wyrick
Nov 7, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Eleni SoilemeziDimitrios Matamis
Oct 6, 2012·Exercise and Sport Sciences Reviews·Tony G Babb
Sep 1, 1993·Annals of Biomedical Engineering·Y OkuN S Cherniack
Nov 29, 2020·Revue des maladies respiratoires·E Zapata-FochA Charloux
Apr 10, 2007·Respiratory Physiology & Neurobiology·Chi-Sang PoonYunguo Yu

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