PMID: 9194536Jun 1, 1997Paper

Effects of insulin and the combination of insulin plus metformin (glucophage) on microvascular reactivity in control and diabetic hamsters

Angiology
E BouskelaN Wiernsperger

Abstract

The purpose of this study was to determine the in vivo microvascular reactivity of arterioles (mean internal diameter range: 16.0 to 106.4 microm) and venules (mean internal diameter range: 24.0 to 117.3 microm) in the hamster cheek pouch to insulin and to the mixture insulin + metformin. Experiments were performed using an intravital microscope coupled to a closed-circuit TV system and a videotape. The TV monitor display was used to obtain arteriolar and venular internal diameter measurements by an image-shearing device. The studied drugs were applied topically, added to the superfusion solution, to avoid systemic effects that would complicate the analysis of the results. In control animals (glycemia 7.7 +/- 0.4 mmol/L), application of insulin (10 to 500 microU/mL/min) evoked vasodilatation in a dose-dependent fashion in arterioles (4.9 +/- 3.2% to 50.9 +/- 6.5%, smallest and largest concentration, respectively, values expressed in percent of the initial diameter as mean +/- SE) and venules (-2.1 +/- 3.1% to 14.3 +/- 5.1%), decreased and finally abolished the spontaneous vasomotion frequency (from 9.5 +/- 0.3 cycles per minute [cpm] to 0.0 +/- 0.0 cpm) and amplitude (from 8.6 +/- 0.3 to 0.0 +/- 0.0 microm). Addition of metform...Continue Reading

References

Aug 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·M D FlynnP J Watkins
Feb 1, 1992·Diabetologia·J Hilsted, N J Christensen
Jun 1, 1991·The Journal of Clinical Investigation·E A AndersonA L Mark
May 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·J E Tooke
Oct 1, 1986·Japanese Circulation Journal·M YamamotoN Hattori
Aug 7, 1985·European Journal of Pharmacology·P D'Orléans-JusteD Regoli
Mar 1, 1972·Clinical Science·J D Coffman
Sep 1, 1984·Journal of Cardiovascular Pharmacology·C R SirtoriA Bondioli
Nov 1, 1984·British Journal of Pharmacology·Z B FortesR Scivoletto
Oct 1, 1993·The Journal of Clinical Investigation·L A Juncos, S Ito
Jun 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P R StandleyJ R Sowers
Sep 1, 1995·Diabetes/metabolism Reviews·N Wiernsperger, J R Rapin
Sep 17, 1954·Science·D GITLIN, C A JANEWAY

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Citations

Jul 27, 2001·Diabetes Technology & Therapeutics·N F Wiernsperger
Nov 13, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·C AngM A Lumsden
Apr 27, 2011·Acta Physiologica·C AalkjærV Matchkov
Jun 11, 2014·Journal of the American Medical Directors Association·John E Morley
Dec 5, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M SiegristM Halle
Nov 3, 2009·The Journal of Physiology·N Wiernsperger, E Bouskela
Sep 2, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·M F MeyerH H Klein

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