PMID: 2113769Jun 1, 1990Paper

Effects of insulin on skeletal muscle glucose storage, oxidation, and glycolysis in humans

The American Journal of Physiology
D E KelleyL J Mandarino

Abstract

The effects of physiological hyperinsulinemia (approximately 75 mU/l) on glucose storage, oxidation, and glycolysis in skeletal muscle were assessed with euglycemic clamps performed in seven healthy volunteers, in conjunction with leg balance for glucose, lactate, alanine, O2, and CO2. Infusion of insulin increased leg glucose uptake, storage, and oxidation but did not alter net release of lactate and alanine. The respiratory quotient (RQ) across the leg increased from a basal value of 0.74 +/- 0.02 to 0.99 +/- 0.02 during hyperinsulinemia. Under conditions of insulin stimulation, 49 +/- 5% of leg glucose uptake was stored, 37 +/- 4% was oxidized, and 14 +/- 2% was released as lactate and alanine. We conclude that during physiological hyperinsulinemia and euglycemia 1) skeletal muscle lipid oxidation is nearly entirely suppressed and glucose becomes the primary oxidative substrate of muscle, 2) glucose storage and oxidation are the major pathways of skeletal muscle glucose metabolism and are quantitatively similar at physiological insulin levels, and 3) the majority of insulin-stimulated glycolysis is oxidized, with only a small portion released as lactate or alanine.

References

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Citations

Aug 14, 2001·American Journal of Physiology. Endocrinology and Metabolism·D J DyckA Bonen
Sep 28, 2002·Diabetes·David E KelleyVladimir B Ritov
Oct 22, 2015·American Journal of Physiology. Endocrinology and Metabolism·Leo Ka Yu Chan, Po Sing Leung
Mar 25, 2010·American Journal of Physiology. Endocrinology and Metabolism·Yanjun LiJohn P Kirwan
Jun 11, 2002·Annual Review of Nutrition·David E KelleyLen Storlien
Jun 12, 2008·American Journal of Physiology. Endocrinology and Metabolism·Yun Chau Long, Juleen R Zierath
Apr 8, 2020·Journal of Cellular and Molecular Medicine·Miriayi AlimujiangJun Yin
Jan 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Michael G ClarkStephen Rattigan
May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·A A OsmanL J Mandarino
Nov 22, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jonathan D KasperRobert W Wiseman
Sep 24, 2020·American Journal of Physiology. Cell Physiology·Kai ZouJoseph A Houmard
Sep 1, 2021·Obesity·Abel M MengesteJenny Lund
May 25, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ann M Petersen, Todd T Gleeson

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