PMID: 698215Sep 11, 1978Paper

Effects of insulin on the uptake of D-galactose by isolated rat epididymal fat cells

Biochimica Et Biophysica Acta
F V Vega, T Kono

Abstract

In muscle, insulin stimulates uptake of D-galactose as well as D-glucose and certain other sugar isomers (Kono, T. and Colowick, S.P. (1961) Arch. Biochem. Biophys. 93, 514--519). In fat cells, the hormone also stimulates uptake of D-glucose and certain other monosaccharides. Nonetheless, the hormone does not increase the uptake, as determined by the utilization, of D-galactose by fat cells (Ball, E.G. and Cooper, O. (1960) J. Biol. Chem. 235, 584--588; Kuo, J.F. and Dill, I.K. (1969) Biochim. Biophys. Acta 177, 17--26). As pointed out by Ball and Cooper, this does not necessarily indicate that insulin has no effect on the membrane transport of D-galactose in fat cells. The possible effect of the hormone on transport may not be seen in the utilization data if the intracellular metabolism is considerably slower than the rate of transport and insensitive to insulin.

References

Nov 24, 1972·Biochimica Et Biophysica Acta·J GliemannS Gammeltoft
Jun 1, 1961·Archives of Biochemistry and Biophysics·T KONO, S P COLOWICK

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Citations

Mar 1, 1983·Metabolism: Clinical and Experimental·C A WilliamsI Macdonald
Dec 15, 1980·Experientia·C B DelpechD T Plummer
Jul 30, 2020·The Journal of Biological Chemistry·James R KrycerDavid E James

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