Effects of intensive application of retinoic acid on human skin.

The British Journal of Dermatology
K H KaidbeyH Yoshida

Abstract

The daily application of 0-3% retinoic acid to the back produced an acute irritant dermatitis which resolved to a near-normal clinical appearance within 40 days despite continued daily exposure. Hardened skin was markedly altered physiologically. The responses to DMSO, histamine and the histamine liberator, compound 48/80, were sharply enhanced. This reflected enhanced permeability resulting from reduction of the horny layer to less than one-half its normal thickness. Phototoxic and irritant substances produced exaggerated reactions owing to greater penetration. A paradoxical decrease in delayed sinsitivity to streptodornase-streptokinase was attributed to enhanced clearance of the antigen.

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Citations

Feb 1, 1997·Journal of the American Academy of Dermatology·C A SanderG Plewig
Jun 1, 1975·The British Journal of Dermatology·T A Robinson, A M Kligman
Jun 1, 1979·The British Journal of Dermatology·A E Solomon, N J Lowe
Nov 26, 2010·Obstetrics and Gynecology Clinics of North America·Anetta E ReszkoMary P Lupo
Oct 24, 2009·Dermatologic Clinics·Anetta E ReszkoMary P Lupo
Jul 1, 1984·The British Journal of Dermatology·M Prunieras, C Delescluse
Jul 30, 2010·The Journal of Dermatological Treatment·Jerry TanLinda Stein Gold
Jul 2, 2003·Journal of the American Academy of Dermatology·Harald GollnickUNKNOWN Global Alliance to Improve Outcomes in Acne
Jan 29, 2017·Photochemistry and Photobiology·Mary D BoudreauGreg R Olson
Apr 1, 1986·International Journal of Dermatology·L PuigJ M de Moragas
Feb 28, 2002·Expert Opinion on Pharmacotherapy·Richard M Niles
Nov 1, 1978·International Journal of Dermatology·R L RietschelC W Lewis
Nov 1, 1977·The Journal of Investigative Dermatology·G L PeckB Wetzel

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