Effects of interacting networks of cardiovascular risk genes on the risk of type 2 diabetes mellitus (the CODAM study).

BMC Medical Genetics
Marleen M J van GreevenbroekTjerk W A de Bruin

Abstract

Genetic dissection of complex diseases requires innovative approaches for identification of disease-predisposing genes. A well-known example of a human complex disease with a strong genetic component is Type 2 Diabetes Mellitus (T2DM). We genotyped normal-glucose-tolerant subjects (NGT; n = 54), subjects with an impaired glucose metabolism (IGM; n = 111) and T2DM (n = 142) subjects, in an assay (designed by Roche Molecular Systems) for detection of 68 polymorphisms in 36 cardiovascular risk genes. Using the single-locus logistic regression and the so-called haplotype entropy, we explored the possibility that (1) common pathways underlie development of T2DM and cardiovascular disease -which would imply enrichment of cardiovascular risk polymorphisms in "pre-diabetic" (IGM) and diabetic (T2DM) populations- and (2) that gene-gene interactions are relevant for the effects of risk polymorphisms. In single-locus analyses, we showed suggestive association with disturbed glucose metabolism (i.e. subjects who were either IGM or had T2DM), or with T2DM only. Moreover, in the haplotype entropy analysis, we identified a total of 14 pairs of polymorphisms (with a false discovery rate of 0.125) that may confer risk of disturbed glucose metab...Continue Reading

References

Aug 12, 1998·Diabetes Research and Clinical Practice·D AgardhA Lernmark
Aug 26, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·D L Rainwater, S M Haffner
May 25, 1999·Human Mutation·J P KrausM Gaustadnes
Feb 28, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Michael StumvollHans Häring
Jun 25, 2002·Annals of the New York Academy of Sciences·Leslie BaierClifton Bogardus
Jul 12, 2002·Clinical and Experimental Hypertension : CHE·Esteban PochAlejandro de la Sierra
Jul 18, 2002·Clinical Genetics·I A LarsonE J Schaefer
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Ali H MokdadJames S Marks
Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Feb 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Margriet KruijshoopTjerk W A de Bruin
Mar 30, 2004·Diabetes·Carl D LangefeldUNKNOWN Insulin Resistance Atherosclerosis Study Family Study
Jan 22, 2005·Science·Stephen O'RahillyNicholas J Wareham
Feb 9, 2005·Hypertension·Xiuqing GuoJerome I Rotter
Jun 1, 2005·Human Heredity·Jian ZhangMargret R Hoehe

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Citations

Dec 8, 2020·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Wenru LiTiantian Zhu

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Methods Mentioned

BETA
dissection
genotyping

Software Mentioned

SPSS
MS
Splus

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