Effects of interfacial layer wettability and thickness on the coating morphology and sirolimus release for drug-eluting stent

Journal of Colloid and Interface Science
Tarek M BedairDong Keun Han

Abstract

Drug-eluting stents (DESs) have been used to treat coronary artery diseases by placing in the arteries. However, current DESs still suffer from polymer coating defects such as delamination and peeling-off that follows stent deployment. Such coating defects could increase the roughness of DES and might act as a source of late or very late thrombosis and might increase the incident of restenosis. In this regard, we modified the cobalt-chromium (Co-Cr) alloy surface with hydrophilic poly(2-hydroxyethyl methacrylate) (PHEMA) or hydrophobic poly(2-hydroxyethyl methacrylate)-grafted-poly(caprolactone) (PHEMA-g-PCL) brushes. The resulting surfaces were biocompatible and biodegradable, which could act as anchoring layer for the drug-in-polymer matrix coating. The two modifications were characterized by ATR-FTIR, XPS, water contact angle measurements, SEM and AFM. On the control and modified Co-Cr samples, a sirolimus (SRL)-containing poly(D,L-lactide) (PDLLA) were ultrasonically spray-coated, and the drug release was examined for 8weeks under physiological conditions. The results demonstrated that PHEMA as a primer coating improved the coating stability and degradation morphology, and drug release profile for short-term as compared to ...Continue Reading

References

Jul 8, 1999·Biomaterials·C E HolyM S Shoichet
Feb 1, 2002·Current Eye Research·S TongeB Tighe
Sep 7, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Kelvin Chan, Karen K Gleason
Sep 6, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Nina AddenHenning Menzel
Jun 3, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Gopinath ManiC Mauli Agrawal
Sep 17, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Mounir W Z BasalusClemens von Birgelen
Apr 2, 2010·ACS Applied Materials & Interfaces·Yulia ShaulovAbraham J Domb
Oct 25, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Jiyeon ChoiDong Keun Han
Nov 16, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Saami K YazdaniRenu Virmani
Mar 1, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wahid KhanAbraham J Domb
Apr 17, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Motoyasu KobayashiAtsushi Takahara
Jul 23, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Mounir W Z BasalusRobert A Byrne
Jun 24, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Tarek M BedairDong Keun Han
Sep 10, 2014·Colloids and Surfaces. B, Biointerfaces·Tarek M BedairDong Keun Han
Dec 3, 2014·Journal of Colloid and Interface Science·Se Woong ParkIl Keun Kwon

❮ Previous
Next ❯

Citations

Aug 18, 2016·Scientific Reports·Ariane BérardJason R Tavares
Oct 11, 2017·Journal of Tissue Engineering·Tarek M BedairDong Keun Han
Sep 19, 2018·Journal of Biomaterials Applications·Tarek M BedairDong Keun Han
Apr 7, 2021·Biotechnology and Bioprocess Engineering : BBE·Younghak ChoSung Gap Im

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.