Abstract
Triamcinolone acetonide intralesional injection (TAIL) has been used for the treatment of keloids, but only with limited success. Interferon-alpha (IFN-alpha) is the most widely used IFN, and has mainly antiviral, antiproliferative, and antitumoral functions. A few studies have evaluated the efficacy of IFN-alpha2b in controlled trials for the treatment of keloids. To compare the efficacy and side-effects of keloid treatment using IFN-alpha2b and TAIL, and TAIL only. Twenty lesions (combined TAIL + IFN-alpha2b group) and 20 control lesions (TAIL-only group) were studied in 19 patients (14 women and five men). The age range was 7-51 years (mean age, 24.6 years). Both groups were treated with TAIL every 2 weeks. The combined TAIL + IFN-alpha2b group was treated with intralesional injection of IFN-alpha2b, twice a week. Lesion measurements were made using thread, glue, and alginate. Statistically significant decreases in depth (81.6%, P = 0.005) and volume (86.6%, P = 0.002) were observed in lesions of the combined TAIL + IFN-alpha2b group. In the TAIL-only group, the decreases in depth (66.0%, P = 0.281) and volume (73.4%, P = 0.245) were less statistically significant. The main side-effects were fever and flu-like symptoms, mild...Continue Reading
References
Jul 1, 1992·Journal of Clinical Immunology·R L McCauleyM C Robson
Jan 1, 1991·Annual Review of Physiology·M Klagsbrun, P A D'Amore
Jan 1, 1990·British Journal of Plastic Surgery·D D Datubo-Brown
May 1, 1988·Blut·G Gastl, C Huber
Oct 1, 1989·Journal of the American Academy of Dermatology·B Berman, M R Duncan
Apr 1, 1987·The Journal of Clinical Investigation·R D GransteinE P Amento
Jan 18, 1988·Biochimica Et Biophysica Acta·V M KähäriE Vuorio
May 1, 1985·Arthritis and Rheumatism·S A JimenezJ Rosenbloom
Sep 1, 1984·The Journal of Clinical Investigation·S A JimenezJ Rosenbloom
Apr 1, 1981·Journal of the American Academy of Dermatology·J C MurrayS R Pinnell
Feb 1, 1980·The Journal of Clinical Investigation·J H KornE C LeRoy
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·R K SinghI J Fidler
Nov 21, 1997·Journal of the American Academy of Dermatology·B Berman, F Flores
Jan 15, 1999·International Journal of Dermatology·D S Hurd, E T Conte
Citations
Dec 5, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jennifer A LedonKeyvan Nouri
Nov 5, 2013·Burns : Journal of the International Society for Burn Injuries·Rajeev B Ahuja, Pallab Chatterjee
Feb 20, 2016·American Journal of Clinical Dermatology·Anthony P TraceValerie M Harvey
Aug 14, 2013·Expert Opinion on Pharmacotherapy·Chenyu Huang, Rei Ogawa
Jun 28, 2017·Plastic and Reconstructive Surgery·Hung-Chang ChenYen-Chang Hsiao
Jul 10, 2008·The International Journal of Lower Extremity Wounds·Claude Roques, Luc Téot
Mar 3, 2018·International Journal of Molecular Sciences·Ho Jun Lee, Yong Ju Jang
Sep 21, 2010·The British Journal of Dermatology·F SyedA Bayat
Jun 2, 2009·Plastic and Reconstructive Surgery·Gottfried Lemperle, Nelly Gauthier-Hazan
Mar 3, 2015·Annals of Plastic Surgery·Shih-Yi YangYen-Chang Hsiao
Jun 28, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Brian BermanBrian Raphael
May 20, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ahmed Hany WeshayFaisal Nour-Edin
Mar 27, 2015·Journal of Cosmetic Dermatology·Eman ShaarawyRania M Abdel Hay
Jan 15, 2016·Khirurgiia·V I SharobaroA A Baeva
Feb 3, 2012·ANZ Journal of Surgery·Jun-Jie ChenHuai-Sheng Wang
Sep 4, 2012·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander NastUNKNOWN German Society of Dermatology
Jan 1, 2015·Burns and Trauma·Aurelia Trisliana PerdanasariDavide Lazzeri
Jan 31, 2016·Journal of Cosmetic Dermatology·Fabiano SvolacchiaGiuseppe A Ferraro
Aug 7, 2019·Archives of Dermatological Research·Seung Hyo JungSoon Heum Kim
Aug 28, 2020·Scars, Burns & Healing·Nkemcho OjehAndrew LeRoy Forde
Aug 24, 2012·Dermatologic Therapy·Ahmed Hany Weshahy, Rania Abdel Hay
Aug 20, 2021·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Zhendong LiuJingcheng Wang