Effects of interferon-gamma and tumor necrosis factor-alpha on clonogenic growth of cell lines and primary cultures from human gliomas and brain metastases

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
E HelsethG Unsgaard

Abstract

In this study we tested the effect of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) and a combination of these immunotherapeutics on clonogenic growth of cell lines and primary cultures of malignant human brain tumors. Out of 29 primary cultures studied, 5 were inhibited 50% or more by IFN-gamma (10 ng/ml), 6 were inhibited 50% or more by TNF-alpha (10 ng/ml) and 14 were inhibited 50% or more by a combination of IFN-gamma (10 ng/ml) and TNF-alpha (10 ng/ml). The doses of the immunotherapeutics used in this in vitro study are achievable in serum after intravenous administration of IFN-gamma and TNF-alpha without causing unacceptable side effects. We believe that some glioma patients and some patients with brain metastases will benefit from receiving treatment with IFN-gamma, TNF-alpha or a combination of these immunotherapeutics. The patients should be selected for treatment with these immunotherapeutics according to in vitro sensitivity results.

References

Nov 8, 1985·Science·L J Old
Sep 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E HelsethL R Lund
Jan 1, 1988·Journal of Neurosurgery·P L Kornblith, M Walker
Oct 1, 1987·Journal of Interferon Research·H StranderA Szamosi
Mar 1, 1987·The Annals of Thoracic Surgery·P A Kirschner
Jan 1, 1985·Journal of Neuro-oncology·G UnsgaardR Ringkjøb
Jan 1, 1984·Neurosurgical Review·M Nagai, T Arai
Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACS, J LINDENMANN

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Citations

Jul 1, 1992·Journal of Neurosurgery·K L BlackJ E Merrill
Feb 23, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pedro Roda-Navarro, Hugh T Reyburn
Apr 1, 1991·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·N MatsubaraK Orita

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