PMID: 8595930Dec 1, 1995Paper

Effects of interferon-gamma on cell differentiation and cytokine production of a human monoblast cell line, U937

Inflammation
T IshizukaM Mori

Abstract

The U937 cell, a human monoblast cell line, has been used as a model to study the function of human monocytes. We investigated the effects of interferon-gamma (IFN-gamma) on superoxide anion (O2-) production, cell surface antigens, and cytokine production of U937 cells. IFN-gamma treatment enhanced O2- production of fMLP or PMA-stimulated U937 cells. IFN-gamma increased the ratio of CD23 and CD11b positive cells. The fluorescence intensity of CD14 and CD25 was enhanced by IFN-gamma treatment. U937 cells produced IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha by lipopolysaccharide (LPS) stimulation. IFN-gamma treatment enhanced TNF-alpha production, but decreased IL-6 production. These results suggest that IFN-gamma differentiates U937 cells to monocyte-like cells and it regulates the production systems of IL-6 and TNF-alpha separately in U937 cells.

References

May 15, 1976·International Journal of Cancer. Journal International Du Cancer·C Sundström, K Nilsson
Aug 1, 1992·Journal of Interferon Research·T M SchepersK R McLeish
Oct 19, 1990·Journal of Immunological Methods·N IdaM Kohase
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PèneJ Banchereau
Apr 1, 1984·The Journal of Clinical Investigation·I U SchraufstätterC G Cochrane

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Citations

Mar 3, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C F M EvansD Kumar
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·J AnD C Leitman
Oct 2, 2004·Journal of Leukocyte Biology·Ramsey H McIntireJoan S Hunt
May 29, 2000·The Journal of Nutrition·Z L Huang, M L Failla

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